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In this review, we consider the key developments in our understanding of this gaseous signalling molecule in the context of health and disease, discuss potential mechanisms through which H2S can influence processes central to ageing and highlight the emergence of novel H2S-based therapeutics. We also consider the major challenges that may potentially hinder the development of such therapies.<\/jats:p>","DOI":"10.1042\/bcj20210517","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T09:34:06Z","timestamp":1633772046000},"page":"3485-3504","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Hydrogen sulfide in ageing, longevity and disease"],"prefix":"10.1042","volume":"478","author":[{"given":"Stephen E.","family":"Wilkie","sequence":"first","affiliation":[{"name":"Glasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Borland","sequence":"additional","affiliation":[{"name":"Glasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick N.","family":"Carter","sequence":"additional","affiliation":[{"name":"Molecular Metabolism Group, University\/BHF Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Morton","sequence":"additional","affiliation":[{"name":"Molecular Metabolism Group, University\/BHF Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8727-0593","authenticated-orcid":false,"given":"Colin","family":"Selman","sequence":"additional","affiliation":[{"name":"Glasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"key":"2021112218255485100_BCJ-2021-0517C1","doi-asserted-by":"publisher","first-page":"16831","DOI":"10.1073\/pnas.1102008108","article-title":"Increased transsulfuration mediates longevity and dietary restriction in drosophila","volume":"108","year":"2011","journal-title":"Proc. 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