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Here, we used 293 and A549 cells as an accessible cell source to search for endogenous protein interaction partners of TBX18 by an unbiased proteomic approach. We tagged endogenous TBX18 by CRISPR\/Cas9 targeted genome editing with a triple FLAG peptide, and identified by anti-FLAG affinity purification and subsequent LC\u2013MS analysis the ZMYM2 protein to be statistically enriched together with TBX18 in both 293 and A549 nuclear extracts. Using a variety of assays, we confirmed the binding of TBX18 to ZMYM2, a component of the CoREST transcriptional corepressor complex. Tbx18 is coexpressed with Zmym2 in the mesenchymal compartment of the developing ureter of the mouse, and mutations in TBX18 and in ZMYM2 were recently linked to congenital anomalies in the kidney and urinary tract (CAKUT) in line with a possible in vivo relevance of TBX18\u2013ZMYM2 protein interaction in ureter development.<\/jats:p>","DOI":"10.1042\/bcj20210642","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T11:31:44Z","timestamp":1640172704000},"page":"91-109","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Proteomic analysis identifies ZMYM2 as endogenous binding partner of TBX18 protein in 293 and A549 cells"],"prefix":"10.1042","volume":"479","author":[{"given":"Timo H.-W.","family":"L\u00fcdtke","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Jens","family":"Kleppa","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginaldo","family":"Rivera-Reyes","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fairouz","family":"Qasrawi","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dervla M.","family":"Connaughton","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine and Dentistry, University of Western Ontario, 1151 Richmond St, London, ON N6A 5C1, Canada"},{"name":"Department of Medicine, Division of Nephrology, London Health Sciences Centre, 339 Windermere Road, London, ON N6A 5A5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirlee","family":"Shril","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedhelm","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8154-0257","authenticated-orcid":false,"given":"Andreas","family":"Kispert","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2022,1,14]]},"reference":[{"key":"2022011413152929100_BCJ-2021-0642C1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.ctdb.2016.06.004","article-title":"Evolution and classification of the T-box transcription factor family","volume":"122","year":"2017","journal-title":"Curr. 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