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The different experimental and genetic models that have been used to draw conclusions about the role of AMPK in the control of liver gluconeogenesis are critically discussed. The effects of several anti-diabetic drugs, particularly metformin, on hepatic gluconeogenesis are also considered. We conclude that the main effect of AMPK activation pertinent to the control of hepatic gluconeogenesis is to antagonize glucagon signalling in the short-term and, in the long-term, to improve insulin sensitivity by reducing hepatic lipid content.<\/jats:p>","DOI":"10.1042\/bcj20220582","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T07:10:31Z","timestamp":1673593831000},"page":"105-125","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["AMPK inhibits liver gluconeogenesis: fact or fiction?"],"prefix":"10.1042","volume":"480","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-5949","authenticated-orcid":false,"given":"Manuel","family":"Johanns","sequence":"first","affiliation":[{"name":"Universit\u00e9 catholique de Louvain and de Duve Institute, Avenue Hippocrate 75, B-1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Hue","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain and de Duve Institute, Avenue Hippocrate 75, B-1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2655-8921","authenticated-orcid":false,"given":"Mark H.","family":"Rider","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain and de Duve Institute, Avenue Hippocrate 75, B-1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"2023011312100513400_BCJ-2022-0582C1","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1152\/ajpendo.1999.277.1.E1","article-title":"AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes","volume":"277","year":"1999","journal-title":"Am. 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