{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:06:49Z","timestamp":1780484809027,"version":"3.54.1"},"reference-count":129,"publisher":"Portland Press Ltd.","issue":"7","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-198099"],"award-info":[{"award-number":["PJT-198099"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020951","name":"Fonds de recherche du Qu\u00e9bec","doi-asserted-by":"publisher","award":["310821"],"award-info":[{"award-number":["310821"]}],"id":[{"id":"10.13039\/501100020951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Over the past decades, global consumption of industrially processed fructose has surged, increasingly separating this sugar from its natural, fiber-rich context. Fructose provides a striking example that not all calories are metabolically equivalent, regardless of their source. Fructose is particularly detrimental to intestinal and hepatic homeostasis, with mounting evidence implicating the gut microbiota as key contributors. Under contemporary dietary patterns, fructose increasingly reaches intestinal regions\u2014and their resident microbial communities\u2014that would normally be spared in healthier nutritional contexts. Here, we review recent advances in understanding gut\u2013liver fructose metabolism and the role of the gut microbiota in linking excess fructose to host dysmetabolism.<\/jats:p>","DOI":"10.1042\/bcj20250136","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:20:26Z","timestamp":1780482026000},"page":"1131-1146","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["When sweetness overflows: fructose influences microbial and metabolic dysregulation"],"prefix":"10.1042","volume":"483","author":[{"given":"Marielle","family":"Cheikh","sequence":"first","affiliation":[{"name":"1Quebec Heart and Lung Institute Research Center, Universit\u00e9 Laval - 2725, Ch. Sainte-Foy, Quebec QC G1V 4G5, Canada"},{"name":"2Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval - 1050 Av. De la M\u00e9decine, Quebec QC G1V 0A6, Canada"},{"name":"3Institute of Nutrition and Functional Foods, Universit\u00e9 Laval - 2440 Bd. Hochelaga, Qu\u00e9bec QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-4154","authenticated-orcid":false,"given":"Fernando","family":"Forato Anh\u00ea","sequence":"additional","affiliation":[{"name":"1Quebec Heart and Lung Institute Research Center, Universit\u00e9 Laval - 2725, Ch. Sainte-Foy, Quebec QC G1V 4G5, Canada"},{"name":"2Department of Medicine, Faculty of Medicine, Universit\u00e9 Laval - 1050 Av. De la M\u00e9decine, Quebec QC G1V 0A6, Canada"},{"name":"3Institute of Nutrition and Functional Foods, Universit\u00e9 Laval - 2440 Bd. Hochelaga, Qu\u00e9bec QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"2026060306202285600_B1","doi-asserted-by":"publisher","first-page":"1263S","DOI":"10.3945\/jn.108.098020","article-title":"Dietary fructose and metabolic syndrome and diabetes","volume":"139","author":"Bantle","year":"2009","journal-title":"J. Nutr."},{"key":"2026060306202285600_B2","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/MED.0b013e328357f0cb","article-title":"Fructose consumption and cancer: is there a connection?","volume":"19","author":"Port","year":"2012","journal-title":"Curr. Opin. Endocrinol. Diab. 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