{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:09:37Z","timestamp":1775819377160,"version":"3.50.1"},"reference-count":157,"publisher":"Portland Press Ltd.","issue":"10","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5,21]]},"abstract":"<jats:p>3',5'-cyclic adenosine monophosphate (cAMP) is a fundamental secondary messenger capable of rapidly amplifying and propagating cellular signals in response to various extracellular stimuli. cAMP plays a significant role in hormone-mediated regulation of renal fluid and electrolyte balance. Impaired signaling of cAMP has been linked to a variety of pathological ramifications in the kidneys. This review explores the physiological functions of exchange proteins directly activated by cAMP (Epac) in renal water balance and the regulation of solute transport in the renal tubule. Additionally, the involvement of Epac signaling in renal pathologies such as acute kidney injury, chronic kidney disease, and polycystic kidney disease is discussed.<\/jats:p>","DOI":"10.1042\/bcj20253103","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T06:57:05Z","timestamp":1747810625000},"page":"553-568","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multifaceted roles of Epac signaling in renal functions"],"prefix":"10.1042","volume":"482","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5397-6897","authenticated-orcid":false,"given":"Oleh","family":"Pochynyuk","sequence":"first","affiliation":[{"name":"1Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5722-0707","authenticated-orcid":false,"given":"Kyrylo","family":"Pyrshev","sequence":"additional","affiliation":[{"name":"1Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3479-1694","authenticated-orcid":false,"given":"Xiaodong","family":"Cheng","sequence":"additional","affiliation":[{"name":"1Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, U.S.A."},{"name":"2Texas Therapeutics Institute, Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"2025052102565819700_BCJ-2025-3103C1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1124\/mol.120.119602","article-title":"Phosphoproteomic identification of vasopressin\/cAMP\/protein kinase a-dependent signaling in kidney","volume":"99","author":"Salhadar","year":"2021","journal-title":"Mol. 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