{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T10:01:33Z","timestamp":1694858493768},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1968,9,1]]},"abstract":"<jats:p>1. Treatment of 3-dehydroretinyl acetate with aqueous hydrobromic acid resulted in the formation of retro-3-dehydroretinyl acetate, which, on alkaline hydrolysis, gave the corresponding alcohol. 2. retro-3-Dehydroretinyl acetate was isomerized to 3-dehydrovitamin A when fed to vitamin A-deficient rats. 3. When retro-3-dehydroretinyl acetate was administered orally, it was hydrolysed to retro-3-dehydroretinol in the rat intestine, isomerized to 3-dehydroretinol and esterified before being transported to the liver for storage. 4. When administered intraperitoneally, both 3-dehydrovitamin A and retro-3-dehydrovitamin A were accumulated in liver and other tissues, whereas after enterectomy 3-dehydrovitamin A was not detected anywhere in the body. 5. The small intestine was shown to be the major site of conversion of retro-3-dehydrovitamin A into 3-dehydrovitamin A. 6. The extent of conversion of retro-3-dehydroretinyl acetate into 3-dehydrovitamin A was much smaller than that of the conversion of retro-retinyl acetate into vitamin A. 7. The biological potency of retro-3-dehydroretinyl acetate, determined by the rat-growth assay, was 2\u00b76% of that all-trans-retinyl acetate, when given orally.<\/jats:p>","DOI":"10.1042\/bj1090293","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T21:36:50Z","timestamp":1439501810000},"page":"293-299","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preparation, properties and metabolism of <i>retro<\/i>-3-dehydroretinyl acetate"],"prefix":"10.1042","volume":"109","author":[{"given":"A. Krishna","family":"Mallia","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Indian Institute of Science, Bangalore 12, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Lakshmanan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Indian Institute of Science, Bangalore 12, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. V.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Indian Institute of Science, Bangalore 12, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. R.","family":"Cama","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Indian Institute of Science, Bangalore 12, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/109\/2\/293\/761404\/bj1090293.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/109\/2\/293\/761404\/bj1090293.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T21:09:30Z","timestamp":1638220170000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/109\/2\/293\/16316\/Preparation-properties-and-metabolism-of-retro-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,9,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1968,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1090293","relation":{},"ISSN":["0306-3283"],"issn-type":[{"value":"0306-3283","type":"print"}],"subject":[],"published":{"date-parts":[[1968,9,1]]}}}