{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:37:48Z","timestamp":1775230668456,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1969,1,1]]},"abstract":"<jats:p>One molecule of rat haemoglobin binds two molecules of triethyltin. The binding sites are located on the globin and there is co-operativity between the sites such that the intrinsic affinity constant at pH8\u00b70 increases from 3\u00b75\u00d7105m\u22121 for the binding of the first triethyltin molecule to 5\u00b70\u00d7105m\u22121 for the binding of the second. Evidence is presented, from pH studies and the kinetics of inhibition due to photo-oxidation, that each binding site contains two histidine residues.<\/jats:p>","DOI":"10.1042\/bj1110129","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T19:18:21Z","timestamp":1439234301000},"page":"129-137","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Evidence for histidine in the triethyltin-binding site of rat haemoglobin"],"prefix":"10.1042","volume":"111","author":[{"given":"M. S.","family":"Rose","sequence":"first","affiliation":[{"name":"Biochemical Mechanisms Section, Toxicology Research Unit, Medical Research Council Laboratories, Carshalton, Surrey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/111\/2\/129\/762510\/bj1110129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/111\/2\/129\/762510\/bj1110129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T02:37:35Z","timestamp":1638239855000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/111\/2\/129\/95400\/Evidence-for-histidine-in-the-triethyltin-binding"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,1,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1969,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1110129","relation":{},"ISSN":["0306-3283"],"issn-type":[{"value":"0306-3283","type":"print"}],"subject":[],"published":{"date-parts":[[1969,1,1]]}}}