{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:59:24Z","timestamp":1758279564763},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1969,9,1]]},"abstract":"<jats:p>Measurements are reported on the kinetics of the lysozyme-catalysed hydrolysis of several \u03b2-aryl di-N-acetylchitobiosides, some of which have been synthesized for the first time. The catalytic rate constants (kcat.) at 45\u00b0 yield a curved Hammett plot (concave up) and the plot of \u0394H\u2021 versus \u0394S\u2021 has a sharp break. Substrates with electron-withdrawing groups exhibit a kinetic deuterium isotope effect (kHcat.\/kDcat.), whereas those with electron-donating groups show no such isotope effect. The results suggest the operation of different mechanisms for the two types of substrates.<\/jats:p>","DOI":"10.1042\/bj1140529","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T19:23:29Z","timestamp":1439234609000},"page":"529-534","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Substituent effect on lysozyme-catalysed hydrolysis of some \u03b2-aryl di-<i>N<\/i>-acetylchitobiosides"],"prefix":"10.1042","volume":"114","author":[{"given":"C. S.","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Chemistry, Carleton University, Ottawa, Ont., Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Y.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Carleton University, Ottawa, Ont., Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"Subbarao","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Carleton University, Ottawa, Ont., Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/114\/3\/529\/764411\/bj1140529.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/114\/3\/529\/764411\/bj1140529.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T18:56:56Z","timestamp":1637953016000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/114\/3\/529\/16745\/Substituent-effect-on-lysozyme-catalysed"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1969,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1140529","relation":{},"ISSN":["0306-3283"],"issn-type":[{"value":"0306-3283","type":"print"}],"subject":[],"published":{"date-parts":[[1969,9,1]]}}}