{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:50:47Z","timestamp":1760889047344},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1972,6,1]]},"abstract":"<jats:p>1. Adjuvant-induced arthritis in rats is accompanied by a loss of activity of the drug-metabolizing enzyme system and a decrease in hepatic cytochrome P-450. 2. Arthritic rats have normal serum and liver cholesterol concentrations. 3. The rate of biogenesis of cholesterol in vivo and in vitro from either [14C]acetate or [14C]mevalonate in arthritic rats was the same as or greater than that found in control rats. 4. Treatment of rats with carbon disulphide (1ml\/kg) resulted in a loss of drug-metabolizing-enzyme activity and increased cholesterol biogenesis. 5. The activity of cholesterol 7\u03b1-hydroxylase in adjuvant-induced arthritic rats did not differ significantly from that in control rats. 6. Rats fed with cholestyramine had an elevated hepatic cholesterol 7\u03b1-hydroxylase activity, but neither the concentration of cytochrome P-450 nor the activity of the drug-hydroxylating enzyme, aminopyrine demethylase, was affected. 7. The relationships between drug hydroxylation and cholesterol metabolism are discussed.<\/jats:p>","DOI":"10.1042\/bj1280237","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T19:44:32Z","timestamp":1439235872000},"page":"237-242","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The role of cytochrome <i>P<\/i>-450 in cholesterol biogenesis and catabolism"],"prefix":"10.1042","volume":"128","author":[{"given":"Sandra D.","family":"Atkin","sequence":"first","affiliation":[{"name":"Beecham Research Laboratories, Nutritional Research Centre, Walton Oaks, Tadworth, Surrey, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen D.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Beecham Research Laboratories, Nutritional Research Centre, Walton Oaks, Tadworth, Surrey, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. D.","family":"English","sequence":"additional","affiliation":[{"name":"Beecham Research Laboratories, Nutritional Research Centre, Walton Oaks, Tadworth, Surrey, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Beecham Research Laboratories, Nutritional Research Centre, Walton Oaks, Tadworth, Surrey, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Cawthorne","sequence":"additional","affiliation":[{"name":"Beecham Research Laboratories, Nutritional Research Centre, Walton Oaks, Tadworth, Surrey, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Green","sequence":"additional","affiliation":[{"name":"Beecham Research Laboratories, Nutritional Research Centre, Walton Oaks, Tadworth, Surrey, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/128\/2\/237\/777119\/bj1280237.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/128\/2\/237\/777119\/bj1280237.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T14:30:27Z","timestamp":1637937027000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/128\/2\/237\/6613\/The-role-of-cytochrome-P-450-in-cholesterol"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,6,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1972,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1280237","relation":{},"ISSN":["0306-3283"],"issn-type":[{"value":"0306-3283","type":"print"}],"subject":[],"published":{"date-parts":[[1972,6,1]]}}}