{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:25:09Z","timestamp":1771003509674,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1973,5,1]]},"abstract":"<jats:p>The formation of \u03b3-glutamylhydroxamate by homogenates under optimum assay condition showed an inconstancy in the ratios of the enzyme activities utilizing l-glutamate and ATP (\u03b3-glutamylhydroxamate synthetase) and l-glutamine and ADP (l-glutamine\u2013hydroxylamine glutamyltransferase) in a number of normal and neoplastic rat tissues. Although \u03b3-glutamylhydroxamate synthetase activities in adult livers and kidneys were identical in males and females, l-glutamine\u2013hydroxylamine glutamyltransferase activities in the organs of females were significantly lower. The developmental formations of the two activities in liver, kidney, brain and muscle were not simultaneous. The l-glutamine\u2013hydroxylamine glutamyltransferase activity in foetal liver or neonatal kidney could be prematurely evoked by thyroxine, but the \u03b3-glutamylhydroxamate synthetase activity remained unchanged. Injections of cortisol also had dissimilar effects on the two activities in thymus and hepatomas. The discrepant tissue distribution, asynchronous developmental formation and differential response to several hormonal stimuli provide evidence in vivo that the two activities are not catalysed by the same protein.<\/jats:p>","DOI":"10.1042\/bj1330059","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T19:49:22Z","timestamp":1439236162000},"page":"59-66","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The distinction between \u03b3-glutamylhydroxamate synthetase and <scp>l<\/scp>-glutamine\u2013hydroxylamine glutamyltransferase activities in rat tissues. Studies <i>in vivo<\/i>"],"prefix":"10.1042","volume":"133","author":[{"given":"Annemarie","family":"Herzfeld","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry, Harvard Medical School, and the Cancer Research Institute, New England Deaconess Hospital, Boston, Mass. 02215, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Nathan A.","family":"Estes","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Harvard Medical School, and the Cancer Research Institute, New England Deaconess Hospital, Boston, Mass. 02215, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/133\/1\/59\/560917\/bj1330059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/133\/1\/59\/560917\/bj1330059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T14:58:39Z","timestamp":1637938719000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/133\/1\/59\/7567\/The-distinction-between-glutamylhydroxamate"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,5,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1973,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1330059","relation":{},"ISSN":["0264-6021"],"issn-type":[{"value":"0264-6021","type":"print"}],"subject":[],"published":{"date-parts":[[1973,5,1]]}}}