{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:08:54Z","timestamp":1787004534017,"version":"build-2736575974"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1973,7,15]]},"abstract":"<jats:p>Pyridoxine deficiency in post-weanling rats caused a marked decrease in body weight and a small but significant decrease in brain weight. Although the concentration of circulating 5-hydroxytryptamine was markedly decreased, the concentrations of 5-hydroxytryptamine and noradrenaline in the brain were not affected. p-Chlorophenylalanine, an inhibitor of 5-hydroxytryptamine synthesis, decreased the 5-hydroxytryptamine content of brain to very low values in both the deficient and control animals, whereas the noradrenaline contents were not appreciably affected. The concentration of 5-hydroxytryptamine in blood, the origin of which is primarily gastrointestinal, was decreased only in the controls but not in the deficient animals after p-chlorophenylalanine treatment. These results suggest that whereas l-tryptophan hydroxylase (EC 1.14.3.2) is rate-limiting in the brain as has been reported by others, the pyridoxal 5\u2032-phosphate-dependent enzyme 5-hydroxytryptophan decarboxylase (EC 4.1.1.28) may be more important in the gastrointestinal tract in the regulation of 5-hydroxytryptamine synthesis.<\/jats:p>","DOI":"10.1042\/bj1340763","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T15:50:06Z","timestamp":1439221806000},"page":"763-767","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of pyridoxine deficiency and\n                    <scp>dl<\/scp>\n                    -\n                    <i>p<\/i>\n                    -chlorophenylalanine administration to rats on 5-hydroxytryptamine and noradrenaline concentrations in brain and 5-hydroxytryptamine concentration in blood"],"prefix":"10.1042","volume":"134","author":[{"given":"Hemmige N.","family":"Bhagavan","sequence":"first","affiliation":[{"name":"Research Institute, St. Joseph Hospital, Lancaster, Pa. 17604, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Coursin","sequence":"additional","affiliation":[{"name":"Research Institute, St. Joseph Hospital, Lancaster, Pa. 17604, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/134\/3\/763\/780593\/bj1340763.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/134\/3\/763\/780593\/bj1340763.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T10:09:49Z","timestamp":1637921389000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/134\/3\/763\/7848\/Effects-of-pyridoxine-deficiency-and-dl-p"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,7,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1973,7,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1340763","relation":{},"ISSN":["0306-3283"],"issn-type":[{"value":"0306-3283","type":"print"}],"subject":[],"published":{"date-parts":[[1973,7,15]]}}}