{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:54:13Z","timestamp":1760885653974},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,6,1]]},"abstract":"<jats:p>The effect of riboflavin deficiency and phenobarbital pretreatment on drug hydroxylation and lipid peroxidation was investigated. A significant decrease in aniline and acetanilide hydroxylation as well as NADPH-linked and ascorbate-induced lipid peroxidation was observed during 4- and 7-week riboflavin deficiency in both adult male and adult female rats. The drug-hydroxylation and lipid-peroxidation activities were further lowered with the increase in riboflavin deficiency. The phenobarbital pretreatment induced aniline and acetanilide hydroxylase activity even in riboflavin-deficient animals. Drug hydroxylation inhibits lipid peroxidation in both deficient and normal rats. The administration of riboflavin was followed by a significant increase in drug hydroxylation and lipid peroxidation.<\/jats:p>","DOI":"10.1042\/bj1400363","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T19:53:43Z","timestamp":1439236423000},"page":"363-368","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatic drug hydroxylation and lipid peroxidation in riboflavin-deficient rats"],"prefix":"10.1042","volume":"140","author":[{"given":"J. M.","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Biochemistry, Department of Chemistry, Marathwada University, Aurangabad (Maharashtra), India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. R.","family":"Galdhar","sequence":"additional","affiliation":[{"name":"Division of Biochemistry, Department of Chemistry, Marathwada University, Aurangabad (Maharashtra), India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. S.","family":"Pawar","sequence":"additional","affiliation":[{"name":"Division of Biochemistry, Department of Chemistry, Marathwada University, Aurangabad (Maharashtra), India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/140\/3\/363\/562304\/bj1400363.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/140\/3\/363\/562304\/bj1400363.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T16:12:52Z","timestamp":1637943172000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/140\/3\/363\/9323\/Hepatic-drug-hydroxylation-and-lipid-peroxidation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,6,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1974,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1400363","relation":{},"ISSN":["0264-6021"],"issn-type":[{"value":"0264-6021","type":"print"}],"subject":[],"published":{"date-parts":[[1974,6,1]]}}}