{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T08:29:51Z","timestamp":1724488191634},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,2,15]]},"abstract":"<jats:p>Adult male rats were subjected either to sham operation or to hypophysectomy and adrenalectomy and maintained for a total of 10 days before treatment with growth hormone. Results of the early effects of growth hormone on the activities of the mixed-function oxidases in rat liver over a 96h period after growth-hormone treatment are presented. 2. Hypophysectomy and adrenalectomy result in decreased body and liver weight and decreased drug metabolism (mixed-function oxidases). Concentrations of electron-transport-system components are also decreased. 3. In the hypophysectomized\/adrenalectomized rats, growth hormone decreases the activities of the liver mixed-function oxidases and the cytochrome P-450 and cytochrome c reductases, as well as decreasing the concentration of cytochrome P-450 compared with that of control rats. Similar but less dramatic results are obtained with sham-operated rats. 4. It is concluded that whereas growth hormone enhances liver growth, including induction of many enzyme activities, it results in a decrease in mixed-function oxidase activity. Apparently, mixed-function oxidase activity decreases in liver when growth (mitogenesis) increases.<\/jats:p>","DOI":"10.1042\/bj1540433","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T20:02:48Z","timestamp":1439236968000},"page":"433-438","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Growth hormone and drug metabolism. Acute effects on microsomal mixed-function oxidase activities in rat liver"],"prefix":"10.1042","volume":"154","author":[{"given":"J T.","family":"Wilson","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Pharmacology Vanderbilt University School of Medicine, Nashville, Tenn. 37232, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T C.","family":"Spelsberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tenn. 37232, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/154\/2\/433\/781811\/bj1540433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/154\/2\/433\/781811\/bj1540433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T13:41:54Z","timestamp":1637934114000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/154\/2\/433\/5153\/Growth-hormone-and-drug-metabolism-Acute-effects"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,2,15]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1976,2,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1540433","relation":{},"ISSN":["0306-3283"],"issn-type":[{"value":"0306-3283","type":"print"}],"subject":[],"published":{"date-parts":[[1976,2,15]]}}}