{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:04:59Z","timestamp":1756994699669},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,6,1]]},"abstract":"<jats:p>RNA was isolated from subribosomal particles of the malaria parasite Plasmodium knowlesi. The nucleotide composition (mole fraction) of the principal species was obtained (S-rRNA, 0.295A, 0.36U, 0.25G, 0.105C: L-rRNA, 0.326A, 0.31U, 0.228G, 0.144C). Ribosomal RNA was also isolated from Drosophila melanogaster. Optical properties of these A + U-rich species were measured. In all four cases analysis of the hypochromic effect revealed that adenine and uracil residues tended to form clusters along the polynucleotide chain. A substantial fraction of residues was located in bihelical regions of approx. 50% G-C base pairs or in regions of approx. 30-35% G-C base pairs. The possible evolutionary significance of these results was considered on the basis of comparison with properties of rRNA from bacteria (Escherichia coli) and a mammal (rabbit reticulocyte).<\/jats:p>","DOI":"10.1042\/bj1550465a","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T20:02:55Z","timestamp":1439236975000},"page":"465-475","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Spectroscopic evidence for the uneven distribution of adenine and uracil residues in ribosomal ribonucleic acid of <i>Drosophila melanogaster<\/i> and of <i>Plasmodium knowlesi<\/i> and its possible evolutionary significance"],"prefix":"10.1042","volume":"155","author":[{"given":"R A","family":"Cox","sequence":"first","affiliation":[{"name":"National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Godwin","sequence":"additional","affiliation":[{"name":"National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Hastings","sequence":"additional","affiliation":[{"name":"The Chester Beatty Research Institute, Fulham Road, London SW3 6JB, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/155\/3\/465\/616332\/bj1550465a.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/155\/3\/465\/616332\/bj1550465a.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T17:16:52Z","timestamp":1637947012000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/155\/3\/465\/10829\/Spectroscopic-evidence-for-the-uneven-distribution"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,6,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1976,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1550465a","relation":{},"ISSN":["0264-6021"],"issn-type":[{"value":"0264-6021","type":"print"}],"subject":[],"published":{"date-parts":[[1976,6,1]]}}}