{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:30:52Z","timestamp":1756992652852},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,4,15]]},"abstract":"<jats:p>The metabolism of [3H]progesterone in the rabbit endometrium and myometrium was studied in vitro. The major metabolities identified were 5alpha-pregnane-3,20-dione, 20alpha-hydroxypregn-4-en-3-one, 3beta-hydroxy-5alpha-preganan-20-one and 5alpha-pregnane-3beta,20alpha-diol. Other minor metabolites tentatively identified were 3alpha-hydroxy-5beta-pregnan-20-one,20alpha-hydroxy-5beta-pregnan-3-one and 5beta-pregnane-3alpha,20alpha-diol. The ability of the endometrium to metabolize progesterone on a unit weight bais was about 2.7 times that of the myometrium. The metabolism of [3H]progesterone in the rabbit uterus under the influnce of oestradiol-17beta and progesterone was studied. The ability of the oestradiol-treated rabbit uterus to metabolize progesterone was increased to 3.47 times that of the overiectomized control uterus, whereas the oestradiol-progesterone-treated rabbit uterus metabolized only 1.86 times that of the control. Study of the metabolism of progesterone with uterine subcellular preparations revealed that the 5alpha-reductase enzyme was present mainly in the nuclear fraction; 20alpha-hydroxysteroid dehydrogenase was found in the cytosol fraction and 3beta-hydroxysteroid dehydrogenase in the particulate fraction of the uterus. The metabolic pathways of progesterone in the rabbit uterine tissue are discussed.<\/jats:p>","DOI":"10.1042\/bj1560055","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T20:03:00Z","timestamp":1439236980000},"page":"55-62","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of oestradiol-17\u03b2 and progesterone on the metabolism of [1,2-3H] progesterone by the rabbit endometrium and myometrium"],"prefix":"10.1042","volume":"156","author":[{"given":"U","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Reproductive Biology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110016, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K R","family":"Laumas","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110016, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/156\/1\/55\/565567\/bj1560055.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/156\/1\/55\/565567\/bj1560055.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T17:04:33Z","timestamp":1637946273000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/156\/1\/55\/10355\/Effect-of-oestradiol-17-and-progesterone-on-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,4,15]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1976,4,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj1560055","relation":{},"ISSN":["0264-6021"],"issn-type":[{"value":"0264-6021","type":"print"}],"subject":[],"published":{"date-parts":[[1976,4,15]]}}}