{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:07:02Z","timestamp":1790554022041,"version":"4.1.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,2,1]]},"abstract":"<jats:p>We postulated that adenosine function could be related to some of the neurological features of Lesch\u2013Nyhan syndrome and therefore characterized adenosine transport in PBLs (peripheral blood lymphocytes) obtained from Lesch\u2013Nyhan patients (PBLLN) and from controls (PBLC). Adenosine transport was significantly lower in PBLLN when compared with that in PBLC and a significantly lower number of high affinity sites for [3H]nitrobenzylthioinosine binding were quantified per cell (Bmax) in PBLLN when compared with that in PBLC. After incubation with 25 \u00b5M hypoxanthine, adenosine transport was significantly decreased in PBLLN with respect to PBLC. Hypoxanthine incubation lowers [3H]nitrobenzylthioinosine binding in PBLC, with respect to basal conditions, but does not affect it in PBLLN. This indicates that hypoxanthine affects adenosine transport in control and hypoxanthine\u2013guanine phosphoribosyltransferase-deficient cells by different mechanisms.<\/jats:p>","DOI":"10.1042\/bj20031035","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T15:30:58Z","timestamp":1194449458000},"page":"733-739","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Adenosine transport in peripheral blood lymphocytes from Lesch-Nyhan patients"],"prefix":"10.1042","volume":"377","author":[{"given":"Rosa J.","family":"TORRES","sequence":"first","affiliation":[{"name":"Clinical Biochemistry Division, \u2018La Paz\u2019 University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"DeANTONIO","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Division, \u2018La Paz\u2019 University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"PRIOR","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Division, \u2018La Paz\u2019 University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan G.","family":"PUIG","sequence":"additional","affiliation":[{"name":"Internal Medicine Division, \u2018La Paz\u2019 University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/377\/3\/733\/713018\/bj3770733.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/377\/3\/733\/713018\/bj3770733.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T12:50:40Z","timestamp":1637585440000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/377\/3\/733\/41118\/Adenosine-transport-in-peripheral-blood"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj20031035","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2,1]]}}}