{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:42:32Z","timestamp":1773661352201,"version":"3.50.1"},"reference-count":59,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,8,1]]},"abstract":"<jats:p>Agonists that deplete intracellular Ca2+ stores also activate Ca2+ entry, although the mechanism by which store release and Ca2+ influx are linked is unclear. A potential mechanism involves \u2018store-operated channels\u2019 that respond to depletion of the intracellular Ca2+ pool. Although SOCE (store-operated Ca2+ entry) has been considered to be the principal route for Ca2+ entry during hormonal stimulation of non-electrically excitable cells, recent evidence has suggested that alternative pathways activated by metabolites such as arachidonic acid are responsible for physiological Ca2+ influx. It is not clear whether such messenger-activated pathways exist in all cells, whether they are truly distinct from SOCE and which metabolites are involved. In the present study, we demonstrate that HeLa cells express two pharmacologically and mechanistically distinct Ca2+ entry pathways. One is the ubiquitous SOCE route and the other is an arachidonate-sensitive non-SOCE. We show that both these Ca2+ entry pathways can provide long-lasting Ca2+ elevations, but that the channels are not the same, based on their differential sensitivity to 2-aminoethoxydiphenyl borate, LOE-908 {(R,S)-(3,4-dihydro-6,7-dimethoxy-isochinolin-1-yl)-2-phenyl-N,N-di[2-(2,3,4-trimethoxyphenyl)ethyl]acetamid mesylate} and gadolinium. In addition, non-SOCE and not SOCE was permeable to strontium. Furthermore, unlike SOCE, the non-SOCE pathway did not require store depletion and was not sensitive to displacement of the endoplasmic reticulum from the plasma membrane using jasplakinolide or ionomycin pretreatment. These pathways did not conduct Ca2+ simultaneously due to the dominant effect of arachidonate, which rapidly curtails SOCE and promotes Ca2+ influx via non-SOCE. Although non-SOCE could be activated by exogenous application of arachidonate, the most robust method for stimulation of this pathway was application of the widely used calmodulin antagonist calmidazolium, due to its ability to activate phospholipase A2.<\/jats:p>","DOI":"10.1042\/bj20040097","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T09:59:52Z","timestamp":1090922392000},"page":"929-939","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells"],"prefix":"10.1042","volume":"381","author":[{"given":"Claire\u00a0M.","family":"PEPPIATT","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony\u00a0M.","family":"HOLMES","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u00a0T.","family":"SEO","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin\u00a0D.","family":"BOOTMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony\u00a0J.","family":"COLLINS","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fraser","family":"McMDONALD","sequence":"additional","affiliation":[{"name":"Bone Research Unit, Department of Orthodontics and Pediatric Dentistry, Floor 22, Guy's Tower, UMDS, London SE1 9RT, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u00a0Llewelyn","family":"RODERICK","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2004,7,27]]},"reference":[{"key":"2021112215021770100_B1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"2021112215021770100_B2","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1242\/jcs.114.12.2223","article-title":"Mechanisms of capacitative calcium entry","volume":"114","author":"Putney","year":"2001","journal-title":"J. Cell Sci."},{"key":"2021112215021770100_B3","doi-asserted-by":"crossref","first-page":"E263","DOI":"10.1038\/ncb1102-e263","article-title":"The cellular and molecular basis of store-operated calcium entry","volume":"4","author":"Venkatachalam","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"2021112215021770100_B4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0143-4160(03)00042-3","article-title":"From TRPs to SOCs, CCEs, and CRACs: consensus and controversies","volume":"33","author":"Nilius","year":"2003","journal-title":"Cell Calcium"},{"key":"2021112215021770100_B5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/35055019","article-title":"Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4\u2212\/\u2212 mice","volume":"3","author":"Freichel","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"2021112215021770100_B6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/01.RES.0000023391.40106.A8","article-title":"Impairment of store-operated Ca2+ entry in TRPC4(\u2212\/\u2212) mice interferes with increase in lung microvascular permeability","volume":"91","author":"Tiruppathi","year":"2002","journal-title":"Circ. Res."},{"key":"2021112215021770100_B7","doi-asserted-by":"crossref","first-page":"13597","DOI":"10.1074\/jbc.M110881200","article-title":"The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293\u00a0cells","volume":"277","author":"Wu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021112215021770100_B8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0014-5793(90)80692-C","article-title":"\u2018Quantal\u2019 Ca2+ release and the control of Ca2+ entry by inositol phosphates \u2013 a possible mechanism","volume":"263","author":"Irvine","year":"1990","journal-title":"FEBS Lett."},{"key":"2021112215021770100_B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3120001","article-title":"Capacitative calcium entry","volume":"312","author":"Berridge","year":"1995","journal-title":"Biochem. J."},{"key":"2021112215021770100_B10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1097-2765(00)00041-1","article-title":"Gating of store-operated channels by conformational coupling to ryanodine receptors","volume":"6","author":"Kiselyov","year":"2000","journal-title":"Mol. Cell"},{"key":"2021112215021770100_B11","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/24890","article-title":"Functional interaction between InsP3 receptors and store-operated Htrp3 channels","volume":"396","author":"Kiselyov","year":"1998","journal-title":"Nature (London)"},{"key":"2021112215021770100_B12","first-page":"127","article-title":"Mechanism of capacitative Ca2+ entry (CCE): interaction between IP3 receptor and TRP links the internal calcium storage compartment to plasma membrane CCE channels","volume":"55","author":"Birnbaumer","year":"2000","journal-title":"Recent Prog. Horm. Res."},{"key":"2021112215021770100_B13","doi-asserted-by":"crossref","first-page":"14955","DOI":"10.1073\/pnas.96.26.14955","article-title":"Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry","volume":"96","author":"Boulay","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112215021770100_B14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(00)81977-7","article-title":"Store-operated Ca2+ entry: evidence for a secretion-like coupling model","volume":"98","author":"Patterson","year":"1999","journal-title":"Cell (Cambridge, Mass.)"},{"key":"2021112215021770100_B15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/bj3560191","article-title":"Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets","volume":"356","author":"Rosado","year":"2001","journal-title":"Biochem. J."},{"key":"2021112215021770100_B16","doi-asserted-by":"crossref","first-page":"R563","DOI":"10.1016\/S0960-9822(02)01055-2","article-title":"Calcium signalling: more messengers, more channels, more complexity","volume":"12","author":"Bootman","year":"2002","journal-title":"Curr. Biol."},{"key":"2021112215021770100_B17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1054\/ceca.1999.0022","article-title":"What drives calcium entry during [Ca2+]i oscillations? Challenging the capacitative model","volume":"25","author":"Shuttleworth","year":"1999","journal-title":"Cell Calcium"},{"key":"2021112215021770100_B18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1469-7793.2000.00159.x","article-title":"Protein kinase C activates non-capacitative calcium entry in human platelets","volume":"529","author":"Rosado","year":"2000","journal-title":"J. Physiol. (Cambridge U.K.)"},{"key":"2021112215021770100_B19","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1042\/bj3580717","article-title":"A diacylglycerol-activated Ca2+ channel in PC12\u00a0cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein","volume":"358","author":"Tesfai","year":"2001","journal-title":"Biochem. J."},{"key":"2021112215021770100_B20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1042\/bj3620013","article-title":"Reciprocal regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells: only the latter operates during receptor activation","volume":"362","author":"Moneer","year":"2002","journal-title":"Biochem. J."},{"key":"2021112215021770100_B21","doi-asserted-by":"crossref","first-page":"35676","DOI":"10.1074\/jbc.M105626200","article-title":"Reciprocal regulation of capacitative and arachidonate-regulated noncapacitative Ca2+ entry pathways","volume":"276","author":"Mignen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2021112215021770100_B22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0092-8674(92)90410-E","article-title":"Epidermal growth factor activates calcium channels by phospholipase A2\/5-lipoxygenase-mediated leukotriene C4 production","volume":"69","author":"Peppelenbosch","year":"1992","journal-title":"Cell (Cambridge, Mass.)"},{"key":"2021112215021770100_B23","doi-asserted-by":"crossref","first-page":"13748","DOI":"10.1074\/jbc.274.20.13748","article-title":"The bell-shaped Ca2+ dependence of the inositol 1,4,5-trisphosphate-induced Ca2+ release is modulated by Ca2+\/calmodulin","volume":"274","author":"Missiaen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2021112215021770100_B24","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0896-6273(01)80037-4","article-title":"Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor","volume":"23","author":"Michikawa","year":"1999","journal-title":"Neuron"},{"key":"2021112215021770100_B25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1570-9639(02)00440-5","article-title":"The role of calmodulin for inositol 1,4,5-trisphosphate receptor function","volume":"1600","author":"Nadif\u00a0Kasri","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"2021112215021770100_B26","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0143416002001859","article-title":"IP3 receptors and their regulation by calmodulin and cytosolic Ca2+","volume":"32","author":"Taylor","year":"2002","journal-title":"Cell Calcium"},{"key":"2021112215021770100_B27","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S1097-2765(02)00506-3","article-title":"Calmodulin regulates Ca2+-dependent feedback inhibition of store-operated Ca2+ influx by interaction with a site in the C terminus of TrpC1","volume":"9","author":"Singh","year":"2002","journal-title":"Mol. Cell"},{"key":"2021112215021770100_B28","doi-asserted-by":"crossref","first-page":"42178","DOI":"10.1074\/jbc.M204531200","article-title":"Calmodulin modulates the delay period between release of calcium from internal stores and activation of calcium influx via endogenous TRP1 channels","volume":"277","author":"Vaca","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021112215021770100_B29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0143416002001550","article-title":"Ca2+-calmodulin regulates receptor-operated Ca2+ entry activity of TRPC6 in HEK-293\u00a0cells","volume":"32","author":"Boulay","year":"2002","journal-title":"Cell Calcium"},{"key":"2021112215021770100_B30","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1073\/pnas.051632698","article-title":"Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain","volume":"98","author":"Zhang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112215021770100_B31","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1042\/bj3130661","article-title":"Calmidazolium leads to an increase in the cytosolic Ca2+ concentration in Dictyostelium discoideum by induction of Ca2+ release from intracellular stores and influx of extracellular Ca2+","volume":"313","author":"Schlatterer","year":"1996","journal-title":"Biochem. J."},{"key":"2021112215021770100_B32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/BF00180683","article-title":"Effects of the calmodulin antagonists fendiline and calmidazolium on aggregation, secretion of ATP, and internal calcium in washed human platelets","volume":"343","author":"Luckhoff","year":"1991","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"2021112215021770100_B33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1677\/joe.0.1480131","article-title":"Inhibition of agonist-mediated calcium entry by calmodulin antagonists and by the Ca2+\/calmodulin kinase II inhibitor KN-62. Studies with thyroid FRTL-5\u00a0cells","volume":"148","author":"Tornquist","year":"1996","journal-title":"J. Endocrinol."},{"key":"2021112215021770100_B34","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/taap.1999.8844","article-title":"Calmidazolium-induced rises in cytosolic calcium concentrations in Madin\u2013Darby canine kidney cells","volume":"162","author":"Jan","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2021112215021770100_B35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0006-2952(00)00349-X","article-title":"Effect of calmidazolium analogs on calcium influx in HL-60\u00a0cells","volume":"60","author":"Harper","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"2021112215021770100_B36","doi-asserted-by":"crossref","first-page":"25113","DOI":"10.1016\/S0021-9258(19)74013-7","article-title":"The thiol reagent, thimerosal, evokes Ca2+ spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor","volume":"267","author":"Bootman","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2021112215021770100_B37","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1242\/jcs.114.12.2213","article-title":"The organisation and functions of local Ca2+ signals","volume":"114","author":"Bootman","year":"2001","journal-title":"J. Cell Sci."},{"key":"2021112215021770100_B38","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0960-9822(02)00609-7","article-title":"Subcellular Ca2+ signals underlying waves and graded responses in HeLa cells","volume":"6","author":"Bootman","year":"1996","journal-title":"Curr. Biol."},{"key":"2021112215021770100_B39","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1096\/fasebj.13.2.365","article-title":"Elementary [Ca2+]i signals generated by electroporation functionally mimic those evoked by hormonal stimulation","volume":"13","author":"Bobanovic","year":"1999","journal-title":"FASEB J."},{"key":"2021112215021770100_B40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0143-4160(03)00026-5","article-title":"2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels","volume":"34","author":"Peppiatt","year":"2003","journal-title":"Cell Calcium"},{"key":"2021112215021770100_B41","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1096\/fj.02-0037rev","article-title":"2-Aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release","volume":"16","author":"Bootman","year":"2002","journal-title":"FASEB J."},{"key":"2021112215021770100_B42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1469-7793.1999.0121z.x","article-title":"A non-capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin","volume":"517","author":"Broad","year":"1999","journal-title":"J. Physiol. (Cambridge U.K.)"},{"key":"2021112215021770100_B43","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1042\/bj3290349","article-title":"Ca2+ entry into PC12\u00a0cells initiated by ryanodine receptors or inositol 1,4,5-trisphosphate receptors","volume":"329","author":"Bennett","year":"1998","journal-title":"Biochem. J."},{"key":"2021112215021770100_B44","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1113\/jphysiol.1997.sp021863","article-title":"Delayed autoregulation of the Ca2+ signals resulting from capacitative Ca2+ entry in bovine pulmonary artery endothelial cells","volume":"498","author":"Madge","year":"1997","journal-title":"J. Physiol. (Cambridge U.K.)"},{"key":"2021112215021770100_B45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/ncb1089","article-title":"A novel mechanism for the store-operated calcium influx pathway","volume":"6","author":"Smani","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"2021112215021770100_B46","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0014-5793(02)03413-0","article-title":"Phospholipase A2 regulation of arachidonic acid mobilization","volume":"531","author":"Balsinde","year":"2002","journal-title":"FEBS Lett."},{"key":"2021112215021770100_B47","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.2337\/diabetes.47.9.1436","article-title":"Ca2+-independent phospholipase A2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets: dissociation from the mechanism of carbachol","volume":"47","author":"Simonsson","year":"1998","journal-title":"Diabetes"},{"key":"2021112215021770100_B48","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1126\/science.287.5458.1647","article-title":"Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels","volume":"287","author":"Ma","year":"2000","journal-title":"Science"},{"key":"2021112215021770100_B49","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1054\/ceca.2000.0108","article-title":"Effects of elevated cytoplasmic calcium and protein kinase C on endoplasmic reticulum structure and function in HEK293\u00a0cells","volume":"27","author":"Pedrosa\u00a0Ribeiro","year":"2000","journal-title":"Cell Calcium"},{"key":"2021112215021770100_B50","first-page":"PC33","article-title":"Elevated cytosolic calcium leads to remodelling of mitochondria and the endoplasmic reticulum","volume":"547P","author":"Roderick","year":"2003","journal-title":"J. Physiol. (Cambridge U.K.)"},{"key":"2021112215021770100_B51","doi-asserted-by":"crossref","first-page":"31174","DOI":"10.1074\/jbc.274.44.31174","article-title":"Discriminating between capacitative and arachidonate-activated Ca2+ entry pathways in HEK293\u00a0cells","volume":"274","author":"Shuttleworth","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2021112215021770100_B52","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/16703","article-title":"Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL","volume":"397","author":"Chyb","year":"1999","journal-title":"Nature (London)"},{"key":"2021112215021770100_B53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0898-6568(00)00140-6","article-title":"Inhibition of the type 1 inositol 1,4,5-trisphosphate-sensitive Ca2+ channel by calmodulin antagonists","volume":"13","author":"Khan","year":"2001","journal-title":"Cell. Signal."},{"key":"2021112215021770100_B54","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/S0006-2952(00)00505-0","article-title":"The effects of phenothiazines and other calmodulin antagonists on the sarcoplasmic and endoplasmic reticulum Ca2+ pumps","volume":"60","author":"Khan","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"2021112215021770100_B55","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/00005344-199910000-00003","article-title":"Direct block of Ca2+ channels by calmidazolium in cultured vascular smooth muscle cells","volume":"34","author":"Sunagawa","year":"1999","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2021112215021770100_B56","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/BF00171328","article-title":"Potentiation of stimulus-induced phosphoinositide breakdown by calmodulin antagonists in C6 glioma cells","volume":"352","author":"Lin","year":"1995","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"2021112215021770100_B57","doi-asserted-by":"crossref","first-page":"21303","DOI":"10.1074\/jbc.M102316200","article-title":"Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels","volume":"276","author":"Tang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2021112215021770100_B58","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1042\/bj3550663","article-title":"The transient receptor potential, TRP4, cation channel is a novel member of the family of calmodulin binding proteins","volume":"355","author":"Trost","year":"2001","journal-title":"Biochem. J."},{"key":"2021112215021770100_B59","doi-asserted-by":"crossref","first-page":"11627","DOI":"10.1073\/pnas.94.21.11627","article-title":"Ca2+-independent inhibition of inositol trisphosphate receptors by calmodulin: redistribution of calmodulin as a possible means of regulating Ca2+ mobilization","volume":"94","author":"Patel","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/381\/3\/929\/719263\/bj3810929.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/381\/3\/929\/719263\/bj3810929.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T19:51:13Z","timestamp":1637610673000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/381\/3\/929\/44378\/Calmidazolium-and-arachidonate-activate-a-calcium"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,27]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj20040097","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,27]]}}}