{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:02:10Z","timestamp":1791352930850,"version":"4.3.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,5,15]]},"abstract":"<jats:p>The assembly of a branched network of actin filaments provides the mechanical propulsion that drives a range of dynamic cellular processes, including cell motility. The Arp2\/3 complex is a crucial component of such filament networks. Arp2\/3 nucleates new actin filaments while bound to existing filaments, thus creating a branched network. In recent years, a number of proteins that activate the filament nucleation activity of Arp2\/3 have been identified, most notably the WASP (Wiskott\u2013Aldrich syndrome protein) family. WASP-family proteins activate the Arp2\/3 complex, and consequently stimulate actin assembly, in response to extracellular signals. Structural studies have provided a significant refinement in our understanding of the molecular detail of how the Arp2\/3 complex nucleates actin filaments. There has also been much progress towards an understanding of the complicated signalling processes that regulate WASP-family proteins. In addition, the use of gene disruption in a number of organisms has led to new insights into the specific functions of individual WASP-family members. The present review will discuss the Arp2\/3 complex and its regulators, in particular the WASP-family proteins. Emphasis will be placed on recent developments in the field that have furthered our understanding of actin dynamics and cell motility.<\/jats:p>","DOI":"10.1042\/bj20040176","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T09:17:42Z","timestamp":1087463862000},"page":"1-17","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":236,"title":["Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2\/3 complex"],"prefix":"10.1042","volume":"380","author":[{"given":"Thomas H.","family":"MILLARD","sequence":"first","affiliation":[{"name":"School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart J.","family":"SHARP","sequence":"additional","affiliation":[{"name":"School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"MACHESKY","sequence":"additional","affiliation":[{"name":"School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/380\/1\/1\/714881\/bj3800001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/380\/1\/1\/714881\/bj3800001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T14:22:11Z","timestamp":1637590931000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/380\/1\/1\/43849\/Signalling-to-actin-assembly-via-the-WASP-Wiskott"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,15]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,5,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj20040176","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,15]]}}}