{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:27:57Z","timestamp":1791325677913,"version":"4.3.1"},"reference-count":57,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,12,15]]},"abstract":"<jats:p>The SMN (survival of motoneuron) protein is mutated in patients with the neurodegenerative disease spinal muscular atrophy. We have shown previously that a high-molecular-mass isoform of FGF (fibroblast growth factor) 2 (FGF-223) is in a complex with SMN [Claus, D\u00f6ring, Gringel, M\u00fcller-Ostermeyer, Fuhlrott, Kraft and Grothe (2003) J. Biol. Chem. 278, 479\u2013485]. FGF-2 is a neurotrophic factor for motoneurons, and is known not only as a classical extracellular growth factor, but also as a nuclear protein. In the present study, we demonstrate that SMN binds to the arginine-rich N-terminus of FGF-223. In turn, FGF-223 interacts with amino acid residues 1\u201390 of the human SMN protein. This sequence displays nucleic-acid-binding capacity and overlaps partially with known binding sites for Gemin2\/SIP1 (SMN-interacting protein 1) and p53. Finally, as a functional consequence of FGF-223 binding to SMN, FGF-223 is in a complex with the small nuclear RNAs U2 and U4. Since SMN functions as an assembly factor for snRNPs (small nuclear ribonucleoprotein particles), these results suggest binding of FGF-223 to snRNPs.<\/jats:p>","DOI":"10.1042\/bj20040801","type":"journal-article","created":{"date-parts":[[2004,12,7]],"date-time":"2004-12-07T12:13:02Z","timestamp":1102421582000},"page":"559-565","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Fibroblast growth factor-223 binds directly to the survival of motoneuron protein and is associated with small nuclear RNAs"],"prefix":"10.1042","volume":"384","author":[{"given":"Peter","family":"CLAUS","sequence":"first","affiliation":[{"name":"Department of Neuroanatomy, Hannover Medical School, OE 4140, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany"},{"name":"Center for Systems Neuroscience (ZSN) Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander-Francisco","family":"BRUNS","sequence":"additional","affiliation":[{"name":"Department of Neuroanatomy, Hannover Medical School, OE 4140, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany"},{"name":"Center for Systems Neuroscience (ZSN) Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"GROTHE","sequence":"additional","affiliation":[{"name":"Department of Neuroanatomy, Hannover Medical School, OE 4140, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany"},{"name":"Center for Systems Neuroscience (ZSN) Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2004,12,7]]},"reference":[{"key":"2021112213571350400_B1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"2021112213571350400_B2","doi-asserted-by":"crossref","first-page":"I37","DOI":"10.1007\/s004150050555","article-title":"The role of SMN in spinal muscular atrophy","volume":"247","author":"Jablonka","year":"2000","journal-title":"J. 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