{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T19:36:53Z","timestamp":1767382613066},"reference-count":61,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"abstract":"<jats:p>A 163\u00a0bp enhancer in the CYP2B2 5\u2032 flank confers PB (phenobarbital) inducibility and constitutes a PBRU (PB response unit). The PBRU contains several transcription factor binding sites, including NR1, NR2 and NR3, which are direct repeats separated by 4\u00a0bp of the nuclear receptor consensus half-site AGGTCA, as well as an ER (everted repeat) separated by 7\u00a0bp (ER-7). Constitutive androstane receptor (CAR)\u2013RXR (retinoic X receptor) heterodimers are known to bind to NR1, NR2 and NR3. Electrophoretic mobility-shift analysis using nuclear extracts from livers of untreated or PB-treated rats revealed binding of several other proteins to different PBRU elements. Using supershift analysis and in vitro coupled transcription and translation, the proteins present in four retarded complexes were identified as TR\u03b2 (thyroid hormone receptor \u03b2), LXR (liver X receptor), HNF-4 (hepatocyte nuclear factor 4) and heterodimers of PBX\u2013PREP1 (pre-B cell homoeobox\u2013Pbx regulatory protein 1). LXR\u2013RXR heterodimers bound to NR3 and TR\u03b2 bound to NR3, NR1 and ER-7, whereas the PBX\u2013PREP1 site is contained within NR2. The HNF-4 site overlaps with NR1. A mutation described previously, GRE1m1, which decreases PB responsiveness, increased the affinity of this site for HNF-4. The PBRU also contains a site for nuclear factor 1. The PBRU thus contains a plethora of transcription factor binding sites. The profiles of transcription factor binding to NR1 and NR3 were quite similar, although strikingly different from, and more complex than, that of NR2. This parallels the functional differences in conferring PB responsiveness between NR1 and NR3 on the one hand, and NR2 on the other.<\/jats:p>","DOI":"10.1042\/bj20041556","type":"journal-article","created":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T05:42:14Z","timestamp":1118122934000},"page":"407-418","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The <i>CYP2B2<\/i> phenobarbital response unit contains binding sites for hepatocyte nuclear factor 4, PBX\u2013PREP1, the thyroid hormone receptor \u03b2 and the liver X receptor"],"prefix":"10.1042","volume":"388","author":[{"given":"Marie-Jos\u00e9e","family":"BEAUDET","sequence":"first","affiliation":[{"name":"Centre de recherche en canc\u00e9rologie de l'Universit\u00e9 Laval, L'H\u00f4tel-Dieu de Qu\u00e9bec, Centre hospitalier universitaire de Qu\u00e9bec, Qu\u00e9bec G1R 2J6, Canada, and D\u00e9partement de biologie, Universit\u00e9 Laval, Qu\u00e9bec G1K 7P4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"DESROCHERS","sequence":"additional","affiliation":[{"name":"Centre de recherche en canc\u00e9rologie de l'Universit\u00e9 Laval, L'H\u00f4tel-Dieu de Qu\u00e9bec, Centre hospitalier universitaire de Qu\u00e9bec, Qu\u00e9bec G1R 2J6, Canada, and D\u00e9partement de biologie, Universit\u00e9 Laval, Qu\u00e9bec G1K 7P4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine\u00a0Amaury","family":"LACHAUD","sequence":"additional","affiliation":[{"name":"Centre de recherche en canc\u00e9rologie de l'Universit\u00e9 Laval, L'H\u00f4tel-Dieu de Qu\u00e9bec, Centre hospitalier universitaire de Qu\u00e9bec, Qu\u00e9bec G1R 2J6, Canada, and D\u00e9partement de biologie, Universit\u00e9 Laval, Qu\u00e9bec G1K 7P4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"ANDERSON","sequence":"additional","affiliation":[{"name":"Centre de recherche en canc\u00e9rologie de l'Universit\u00e9 Laval, L'H\u00f4tel-Dieu de Qu\u00e9bec, Centre hospitalier universitaire de Qu\u00e9bec, Qu\u00e9bec G1R 2J6, Canada, and D\u00e9partement de biologie, Universit\u00e9 Laval, Qu\u00e9bec G1K 7P4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2005,5,24]]},"reference":[{"article-title":"Mammalian Cytochromes P-450, vol. 1","year":"1987","author":"Guengerich","key":"2021112217433943500_B1"},{"key":"2021112217433943500_B2","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(02)11203-7","article-title":"Clinical importance of the cytochromes P450","volume":"360","author":"Nebert","year":"2002","journal-title":"Lancet"},{"key":"2021112217433943500_B3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0163-7258(90)90030-6","article-title":"Enzyme induction in the cytochrome P-450 system","volume":"45","author":"Okey","year":"1990","journal-title":"Pharmacol. 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