{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:18:56Z","timestamp":1791083936229,"version":"4.1.0"},"reference-count":67,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,5,1]]},"abstract":"<jats:p>NPC (Niemann\u2013Pick type\u00a0C) disease is a progressive neurological disorder characterized by defects in intracellular cholesterol trafficking, accumulation of cholesterol in the endosomal system and impaired cholesterol homoeostasis. Although these alterations appear to occur in all NPC1-deficient cell types, the consequences are most profound in the nervous system. Since glial cells are important mediators of brain cholesterol homoeostasis, we proposed that defective generation and\/or function of lipoproteins released by glia might contribute to the neurological abnormalities associated with NPC disease. We found that, as in other cell types, Npc1\u2212\/\u2212 glia accumulate cholesterol intracellularly. We hypothesized that this sequestration of cholesterol in glia might restrict the availability of cholesterol for lipoprotein production. Cerebellar astroglia were cultured from a murine model of NPC disease to compare the lipoproteins generated by these cells and wild-type glia. The experiments demonstrate that the amount of cholesterol in glia-conditioned medium is not reduced by NPC1 deficiency. Similarly, cholesterol efflux to apo (apolipoprotein) A1 or glial expression of the transporter ATP-binding-cassette transporter A1 was not decreased by NPC1 deficiency. In addition, the ratio of apo E:cholesterol and the density distribution of lipoproteins in Npc1\u2212\/\u2212 and Npc1+\/+ glia-conditioned medium are indistinguishable. Importantly, in a functional assay, apo E-containing lipoproteins generated by Npc1\u2212\/\u2212 and Npc1+\/+ glia each stimulate axonal elongation of neurons by approx.\u00a035%. On the basis of these observations, we speculate that the neuropathology characteristic of NPC disease can quite probably be ascribed to impaired processes within neurons in the brain rather than defective lipoprotein production by astroglia.<\/jats:p>","DOI":"10.1042\/bj20041694","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T08:32:50Z","timestamp":1114590770000},"page":"779-788","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Generation and function of astroglial lipoproteins from Niemann\u2013Pick type\u00a0C1-deficient mice"],"prefix":"10.1042","volume":"387","author":[{"given":"Barbara","family":"KARTEN","sequence":"first","affiliation":[{"name":"Canadian Institutes of Health Research Group on the Molecular and Cell Biology of Lipids, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2"},{"name":"Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2S2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"HAYASHI","sequence":"additional","affiliation":[{"name":"Canadian Institutes of Health Research Group on the Molecular and Cell Biology of Lipids, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2"},{"name":"Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2S2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon\u00a0A.","family":"FRANCIS","sequence":"additional","affiliation":[{"name":"Canadian Institutes of Health Research Group on the Molecular and Cell Biology of Lipids, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2"},{"name":"Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2S2"},{"name":"Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2S2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert\u00a0B.","family":"CAMPENOT","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis\u00a0E.","family":"VANCE","sequence":"additional","affiliation":[{"name":"Canadian Institutes of Health Research Group on the Molecular and Cell Biology of Lipids, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2"},{"name":"Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2S2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u00a0E.","family":"VANCE","sequence":"additional","affiliation":[{"name":"Canadian Institutes of Health Research Group on the Molecular and Cell Biology of Lipids, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2"},{"name":"Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2S2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2005,4,26]]},"reference":[{"key":"2021112215001671500_B1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00041433-200104000-00003","article-title":"Cholesterol metabolism in the brain","volume":"12","author":"Dietschy","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"key":"2021112215001671500_B2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.ATV.0000120374.59826.1b","article-title":"Brain cholesterol: long secret life behind a barrier","volume":"24","author":"Bjorkhem","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021112215001671500_B3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/bies.10195","article-title":"Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes?","volume":"25","author":"Pfrieger","year":"2003","journal-title":"Bioessays"},{"key":"2021112215001671500_B4","doi-asserted-by":"crossref","first-page":"14352","DOI":"10.1016\/S0021-9258(18)47945-8","article-title":"Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain","volume":"262","author":"Pitas","year":"1987","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0005-2760(94)00232-N","article-title":"Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid","volume":"1255","author":"Borghini","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"2021112215001671500_B6","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1046\/j.1471-4159.1998.70052070.x","article-title":"Nascent astrocyte particles differ from lipoproteins in CSF","volume":"70","author":"LaDu","year":"1998","journal-title":"J. Neurochem."},{"key":"2021112215001671500_B7","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0022-2275(20)31605-9","article-title":"Characterization of four lipoprotein classes in human cerebrospinal fluid","volume":"42","author":"Koch","year":"2001","journal-title":"J. Lipid Res."},{"key":"2021112215001671500_B8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1172\/JCI115288","article-title":"Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation","volume":"88","author":"Linton","year":"1991","journal-title":"J. Clin. Invest."},{"key":"2021112215001671500_B9","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1471-4159.1990.tb01892.x","article-title":"Synthesis of apolipoprotein A-1 in pig brain microvascular endothelial cells","volume":"54","author":"Weiler-Guttler","year":"1990","journal-title":"J. Neurochem."},{"key":"2021112215001671500_B10","doi-asserted-by":"crossref","first-page":"42781","DOI":"10.1074\/jbc.M207601200","article-title":"ABCA1 and scavenger receptor class B, type\u00a0I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells","volume":"277","author":"Panzenboeck","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0005-2760(87)90295-5","article-title":"Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins","volume":"917","author":"Pitas","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"2021112215001671500_B12","doi-asserted-by":"crossref","first-page":"30001","DOI":"10.1074\/jbc.274.42.30001","article-title":"Unique lipoproteins secreted by primary astrocytes from wild type, apoE (\u2013\/\u2013), and human apoE transgenic mice","volume":"274","author":"Fagan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B13","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.expneurol.2003.10.010","article-title":"L-serine-mediated release of apolipoprotein E and lipids from microglial cells","volume":"185","author":"Mori","year":"2004","journal-title":"Exp. Neurol."},{"key":"2021112215001671500_B14","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1172\/JCI113943","article-title":"A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve","volume":"83","author":"Boyles","year":"1989","journal-title":"J. Clin. Invest."},{"key":"2021112215001671500_B15","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1523\/JNEUROSCI.4315-03.2004","article-title":"Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice","volume":"24","author":"Brecht","year":"2004","journal-title":"J. Neurosci."},{"key":"2021112215001671500_B16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/00001756-199503000-00017","article-title":"Astrocytes synthesize and secrete the lipophilic ligand carrier apolipoprotein D","volume":"6","author":"Patel","year":"1995","journal-title":"Neuroreport"},{"key":"2021112215001671500_B17","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"key":"2021112215001671500_B18","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S1050-1738(98)00017-6","article-title":"Potential role of apoE in structural plasticity in the nervous system; implications for disorders of the central nervous system","volume":"8","author":"Holtzman","year":"1998","journal-title":"Trends Cardiovasc. Med."},{"key":"2021112215001671500_B19","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1046\/j.1471-4159.1999.0731615.x","article-title":"Increased expression of apolipoprotein D following experimental traumatic brain injury","volume":"73","author":"Franz","year":"1999","journal-title":"J. Neurochem."},{"key":"2021112215001671500_B20","doi-asserted-by":"crossref","first-page":"17805","DOI":"10.1016\/S0021-9258(18)38235-8","article-title":"Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I","volume":"265","author":"Boyles","year":"1990","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B21","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/S0022-2275(20)41390-2","article-title":"Effects of apolipoprotein E, \u03b2-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro","volume":"33","author":"Handelman","year":"1992","journal-title":"J. Lipid Res."},{"key":"2021112215001671500_B22","doi-asserted-by":"crossref","first-page":"8373","DOI":"10.1074\/jbc.271.14.8373","article-title":"Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain","volume":"271","author":"Kim","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00041433-199710000-00011","article-title":"Novel members of the low density lipoprotein receptor superfamily and their potential roles in lipid metabolism","volume":"8","author":"Schneider","year":"1997","journal-title":"Curr. Opin. Lipidol."},{"key":"2021112215001671500_B24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0006-8993(96)01321-2","article-title":"Low density lipoprotein receptor-related protein is expressed early and becomes restricted to a somatodendritic domain during neuronal differentiation in culture","volume":"747","author":"Brown","year":"1997","journal-title":"Brain Res."},{"key":"2021112215001671500_B25","doi-asserted-by":"crossref","first-page":"19883","DOI":"10.1074\/jbc.275.26.19883","article-title":"Uptake of lipoproteins for axonal growth of sympathetic neurons","volume":"275","author":"Posse\u00a0de\u00a0Chaves","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B26","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0092-8674(00)80782-5","article-title":"Reeler\/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and apoE receptor 2","volume":"97","author":"Trommsdorff","year":"1999","journal-title":"Cell (Cambridge, Mass.)"},{"key":"2021112215001671500_B27","doi-asserted-by":"crossref","first-page":"33556","DOI":"10.1074\/jbc.273.50.33556","article-title":"Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein","volume":"273","author":"Trommsdorff","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.biochem.71.110601.135342","article-title":"Lipoprotein receptors in the nervous system","volume":"71","author":"Herz","year":"2002","journal-title":"Annu. Rev. Biochem."},{"key":"2021112215001671500_B29","doi-asserted-by":"crossref","first-page":"14009","DOI":"10.1074\/jbc.M313828200","article-title":"Glial cell lipoproteins stimulate axon growth of central nervous system neurons in compartmented cultures","volume":"279","author":"Hayashi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B30","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1126\/science.294.5545.1354","article-title":"CNS synaptogenesis promoted by glia-derived cholesterol","volume":"294","author":"Mauch","year":"2001","journal-title":"Science"},{"key":"2021112215001671500_B31","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.1073\/pnas.90.20.9649","article-title":"Increased amyloid \u03b2-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease","volume":"90","author":"Schmechel","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112215001671500_B32","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type\u00a04 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"2021112215001671500_B33","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/01.ATV.0000054662.44688.9A","article-title":"HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol","volume":"23","author":"Oram","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021112215001671500_B34","doi-asserted-by":"crossref","first-page":"13244","DOI":"10.1074\/jbc.M300044200","article-title":"22R-hydroxycholesterol and 9-cisretinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion","volume":"278","author":"Koldamova","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B35","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.277.5323.228","article-title":"Niemann-Pick C1 disease gene: homology to mediators of cholesterol momeostasis","volume":"277","author":"Carstea","year":"1997","journal-title":"Science"},{"key":"2021112215001671500_B36","first-page":"2625","article-title":"Niemann-Pick disease type\u00a0C: a cellular cholesterol lipidosis","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Pentchev","year":"1995"},{"key":"2021112215001671500_B37","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1023\/A:1022575511354","article-title":"Lipid changes in Niemann-Pick disease type\u00a0C: personal experience and review of the literature","volume":"24","author":"Vanier","year":"1999","journal-title":"Neurochem. Res."},{"key":"2021112215001671500_B38","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1083\/jcb.110.2.295","article-title":"Isolation and characterization of Chinese hamster ovary cell mutants defective in intracellular low density lipoprotein cholesterol trafficking","volume":"110","author":"Cadigan","year":"1990","journal-title":"J. Cell Biol."},{"key":"2021112215001671500_B39","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1083\/jcb.108.5.1625","article-title":"The intracellular transport of low density-derived cholesterol is defective in Niemann-Pick type\u00a0C fibroblasts","volume":"108","author":"Liscum","year":"1989","journal-title":"J. Cell Biol."},{"key":"2021112215001671500_B40","doi-asserted-by":"crossref","first-page":"20179","DOI":"10.1074\/jbc.M001793200","article-title":"Embryonic striatal neurons from Niemann-Pick Type\u00a0C mice exhibit defects in cholesterol metabolism and neurotrophin responsiveness","volume":"275","author":"Henderson","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B41","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1046\/j.1471-4159.2002.01220.x","article-title":"Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann-Pick C1-deficient neurons","volume":"83","author":"Karten","year":"2002","journal-title":"J. Neurochem."},{"key":"2021112215001671500_B42","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1074\/jbc.M205406200","article-title":"Trafficking of cholesterol from cell bodies to distal axons in Niemann Pick C1-deficient neurons","volume":"278","author":"Karten","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B43","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/S0021-9258(18)69086-6","article-title":"Type C Niemann-Pick disease","volume":"263","author":"Sokol","year":"1988","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B44","doi-asserted-by":"crossref","first-page":"17002","DOI":"10.1016\/S0021-9258(18)45483-X","article-title":"Low density lipoprotein (LDL)-mediated suppression of cholesterol synthesis and LDL uptake is defective in Niemann-Pick type\u00a0C fibroblasts","volume":"262","author":"Liscum","year":"1987","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B45","doi-asserted-by":"crossref","first-page":"25517","DOI":"10.1074\/jbc.M302588200","article-title":"NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols","volume":"278","author":"Frolov","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B46","doi-asserted-by":"crossref","first-page":"32569","DOI":"10.1074\/jbc.M304553200","article-title":"Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human Niemann-Pick type\u00a0C disease","volume":"278","author":"Choi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B47","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1073\/pnas.96.4.1657","article-title":"Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann-Pick type\u00a0C disease","volume":"96","author":"Patel","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112215001671500_B48","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/oxfordjournals.jbchem.a133811","article-title":"The process of dissolving apolipoprotein A-I in an aqueous buffer","volume":"91","author":"Yokoyama","year":"1982","journal-title":"J. Biochem. (Tokyo)"},{"key":"2021112215001671500_B49","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1126\/science.277.5323.232","article-title":"Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene","volume":"277","author":"Loftus","year":"1997","journal-title":"Science"},{"key":"2021112215001671500_B50","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/BF02535147","article-title":"Molecular species of glycerophospholipids and sphingomyelins of human plasma: comparison to red blood cells","volume":"24","author":"Myher","year":"1989","journal-title":"Lipids"},{"key":"2021112215001671500_B51","doi-asserted-by":"crossref","first-page":"29919","DOI":"10.1074\/jbc.M203934200","article-title":"Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice","volume":"277","author":"Gong","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B52","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0896-6273(88)90127-4","article-title":"Immunological, morphological, and electrophysiological variation among retinal ganglion cells purified by panning","volume":"1","author":"Barres","year":"1988","journal-title":"Neuron"},{"key":"2021112215001671500_B53","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/ajmg.1320420433","article-title":"Niemann-Pick type-C disease: deficient intracellular transport of exogenously derived cholesterol","volume":"42","author":"Roff","year":"1992","journal-title":"Am. J. Med. Genet."},{"key":"2021112215001671500_B54","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1046\/j.1471-4159.1998.70010242.x","article-title":"Cellular cholesterol storage in the Niemann-Pick disease type\u00a0C mouse is associated with increased expression and defective processing of apolipoprotein D","volume":"70","author":"Suresh","year":"1998","journal-title":"J. Neurochem."},{"key":"2021112215001671500_B55","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1023\/A:1023993405851","article-title":"Apolipoprotein D in the Niemann-Pick type\u00a0C disease mouse brain: an ultrastructural immunocytochemical analysis","volume":"31","author":"Ong","year":"2002","journal-title":"J. Neurocytol."},{"key":"2021112215001671500_B56","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0306-4522(01)00517-6","article-title":"Neurodegeneration in the Niemann-Pick C mouse: glial involvement","volume":"109","author":"German","year":"2002","journal-title":"Neuroscience"},{"key":"2021112215001671500_B57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0306-4522(93)90380-X","article-title":"Molecular profile of reactive astrocytes\u2013implications for their role in neurologic disease","volume":"54","author":"Eddleston","year":"1993","journal-title":"Neuroscience"},{"key":"2021112215001671500_B58","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1750-3639.1994.tb00840.x","article-title":"Structure and transcriptional regulation of the GFAP gene","volume":"4","author":"Brenner","year":"1994","journal-title":"Brain Pathol."},{"key":"2021112215001671500_B59","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0014-4886(03)00345-5","article-title":"Postnatal development of inflammation in a murine model of Niemann-Pick type\u00a0C disease: immunohistochemical observations of microglia and astroglia","volume":"184","author":"Baudry","year":"2003","journal-title":"Exp. Neurol."},{"key":"2021112215001671500_B60","doi-asserted-by":"crossref","first-page":"12045","DOI":"10.1021\/bi970079t","article-title":"Selective down-regulation by protein kinase C inhibitors of apolipoprotein-mediated cellular cholesterol efflux in macrophages","volume":"36","author":"Li","year":"1997","journal-title":"Biochemistry"},{"key":"2021112215001671500_B61","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1194\/jlr.M400007-JLR200","article-title":"The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility","volume":"45","author":"Selva","year":"2004","journal-title":"J. Lipid. Res."},{"key":"2021112215001671500_B62","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0022-2275(20)37844-5","article-title":"Evidence for the distribution of apolipoprotein E between lipoprotein classes in human normocholesterolemic plasma and for the origin of unassociated apolipoprotein E (Lp-E)","volume":"25","author":"Castro","year":"1984","journal-title":"J. Lipid Res."},{"key":"2021112215001671500_B63","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0022-2275(20)42037-1","article-title":"Rapid on-line determination of cholesterol distribution among plasma lipoproteins after high-performance gel filtration chromatography","volume":"32","author":"Kieft","year":"1991","journal-title":"J. Lipid Res."},{"key":"2021112215001671500_B64","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1046\/j.1471-4159.2003.01950.x","article-title":"Lipoproteins produced by ApoE\u2013\/\u2013astrocytes infected with adenovirus expressing human ApoE","volume":"86","author":"Peng","year":"2003","journal-title":"J. Neurochem."},{"key":"2021112215001671500_B65","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1046\/j.1471-4159.1999.0722362.x","article-title":"Differential generation of high-density lipoprotein by endogenous and exogenous apolipoproteins in cultured fetal rat astrocytes","volume":"72","author":"Ito","year":"1999","journal-title":"J. Neurochem."},{"key":"2021112215001671500_B66","doi-asserted-by":"crossref","first-page":"41197","DOI":"10.1074\/jbc.M407962200","article-title":"Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain","volume":"279","author":"Hirsch-Reinshagen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2021112215001671500_B67","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0306-4522(01)00230-5","article-title":"Degeneration of neurons and glia in the Niemann-Pick C mouse is unrelated to the low-density lipoprotein receptor","volume":"105","author":"German","year":"2001","journal-title":"Neuroscience"}],"container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/387\/3\/779\/721592\/bj3870779.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/387\/3\/779\/721592\/bj3870779.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T19:46:34Z","timestamp":1637610394000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/387\/3\/779\/44331\/Generation-and-function-of-astroglial-lipoproteins"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,26]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj20041694","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,26]]}}}