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The fibroblasts are derived from sources within and outwith the liver. Fibroblasts expressing \u03b1-smooth muscle actin (myofibroblasts) may be derived from the transdifferentiation of quiescent hepatic stellate cells. Other fibroblasts emerge from the portal tracts within the liver. At least a proportion of these cells in diseased liver originate from the bone marrow. In addition, fibrogenic fibroblasts may also be generated through liver epithelial (hepatocyte and biliary epithelial cell)\u2013mesenchymal transition. Whatever their origin, it is clear that fibrogenic fibroblast activity is sensitive to (and may be active in) the cytokine and chemokine profiles of liver-resident leucocytes such as macrophages. They may also be a component driving the regeneration of tissue. Understanding the complex intercellular interactions regulating liver fibrogenesis is of increasing importance in view of predicted increases in chronic liver disease and the current paucity of effective therapies.<\/jats:p>","DOI":"10.1042\/bj20071570","type":"journal-article","created":{"date-parts":[[2008,3,14]],"date-time":"2008-03-14T17:04:46Z","timestamp":1205514286000},"page":"1-18","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":255,"title":["Liver fibrosis"],"prefix":"10.1042","volume":"411","author":[{"given":"Karen","family":"Wallace","sequence":"first","affiliation":[{"name":"Clinical and Laboratory Sciences, Institute of Cellular Medicine, Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair\u00a0D.","family":"Burt","sequence":"additional","affiliation":[{"name":"Clinical and Laboratory Sciences, Institute of Cellular Medicine, Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew\u00a0C.","family":"Wright","sequence":"additional","affiliation":[{"name":"Clinical and Laboratory Sciences, Institute of Cellular Medicine, Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2008,3,13]]},"reference":[{"key":"2021112215113144100_B1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.taap.2005.02.029","article-title":"Investigation of toxic metabolites during drug development","volume":"207","author":"Park","year":"2005","journal-title":"Toxicol. 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