{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:18:37Z","timestamp":1791173917147,"version":"4.1.0"},"reference-count":70,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:p>RhoH is a member of the Rho family of small GTP-binding proteins that lacks GTPase activity. Since RhoH is constantly bound by GTP, it is thought to be constitutively active and controlled predominantly by changes in quantitative expression. RhoH is produced specifically in haematopoietic cells and aberrant expression has been linked to various forms of leukaemia. Transcription of the RHOH gene is the first level at which the quantitative levels of the RhoH protein are regulated. Previous studies have demonstrated that RHOH gene transcription is initiated by three distinct promoter regions designated P1, P2 and P3 that define the 5\u2032 end of exons 1, 2 and 4 respectively. In the present study we report that the P3 promoter is largely responsible for RHOH gene transcription in the B-lymphocytic cell line Raji. The P3 promoter contains a minimal promoter region and a repressor region extending from \u2212236 to +67 and +68 to +245 respectively, relative to the 5\u2032 end of exon 4. Chromatin immunoprecipitation demonstrated that two AP1 (activator protein 1) sites in the minimal promoter region bind JunD. When JUND is overexpressed, the endogenous RHOH gene is repressed; however, when JUND is inhibited, expression of endogenous RHOH is induced both in the Raji cell line and AML (acute myeloid leukaemia) cells. In the HCL (hairy cell leukaemia) cell line JOK-1, induction of RHOH increases expression of the \u03b1 isoform of protein kinase C. This downstream target of RHOH is also induced in AML cells by JUND inhibition. Collectively, these data indicate that JunD is an inhibitor of RHOH gene expression.<\/jats:p>","DOI":"10.1042\/bj20100829","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T22:33:00Z","timestamp":1308090780000},"page":"75-88","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Repression of the <i>RHOH<\/i> gene by JunD"],"prefix":"10.1042","volume":"437","author":[{"given":"Laure","family":"Delestr\u00e9","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U.837, Centre Jean-Pierre Aubert, Institut pour la Recherche sur le Cancer de Lille and Universit\u00e9 Lille Nord de France, UDSL, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Berthon","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U.837, Centre Jean-Pierre Aubert, Institut pour la Recherche sur le Cancer de Lille and Universit\u00e9 Lille Nord de France, UDSL, 59000 Lille, France"},{"name":"Service des Maladies du Sang, H\u00f4pital Huriez, CHU de Lille, 59045 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Quesnel","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U.837, Centre Jean-Pierre Aubert, Institut pour la Recherche sur le Cancer de Lille and Universit\u00e9 Lille Nord de France, UDSL, 59000 Lille, France"},{"name":"Service des Maladies du Sang, H\u00f4pital Huriez, CHU de Lille, 59045 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Figeac","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lille Nord de France, UDSL, Universit\u00e9 de Lille 2, 59045 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Kerckaert","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U.837, Centre Jean-Pierre Aubert, Institut pour la Recherche sur le Cancer de Lille and Universit\u00e9 Lille Nord de France, UDSL, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Gali\u00e8gue-Zouitina","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U.837, Centre Jean-Pierre Aubert, Institut pour la Recherche sur le Cancer de Lille and Universit\u00e9 Lille Nord de France, UDSL, 59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl\u00a0Simon","family":"Shelley","sequence":"additional","affiliation":[{"name":"Gundersen Lutheran Medical Foundation, La Crosse, WI 54601, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2011,6,14]]},"reference":[{"key":"2021112214465100800_B1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.gene.2004.08.022","article-title":"Structural features of hematopoiesis-specific RhoH\/ARHH gene: high diversity of 5\u2032-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation","volume":"343","author":"Lahousse","year":"2004","journal-title":"Gene"},{"key":"2021112214465100800_B2","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1128\/MCB.22.4.1158-1171.2002","article-title":"The hematopoieticspecific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function","volume":"22","author":"Li","year":"2002","journal-title":"Mol. 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