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There was also an increase in dcAdoMet in cells derived from patients with Snyder\u2013Robinson syndrome, a rare X-linked recessive human disease caused by SMS gene mutations that greatly reduce the content of spermine synthase. These results suggest that there is an inverse relationship between the amount of spermine synthase protein and the content of dcAdoMet and raise the possibility that some of the abnormalities seen in mammals deficient in spermine synthase might be due to changes in dcAdoMet pools.<\/jats:p>","DOI":"10.1042\/bj20101228","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T12:48:15Z","timestamp":1287406095000},"page":"139-144","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Spermine synthase activity affects the content of decarboxylated <i>S<\/i>-adenosylmethionine"],"prefix":"10.1042","volume":"433","author":[{"given":"Anthony\u00a0E.","family":"Pegg","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Milton S. 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