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In the present review, the current knowledge of unique properties of polyamine metabolism in these parasites is outlined. These properties include prozyme regulation of AdoMetDC (S-adenosylmethionine decarboxylase) activity in trypanosomatids, co-expression of ODC (ornithine decarboxylase) and AdoMetDC activities in a single protein in plasmodia, and formation of trypanothione, a unique compound linking polyamine and thiol metabolism in trypanosomatids. Particularly interesting features within polyamine metabolism in these parasites are highlighted for their potential in selective therapeutic strategies.<\/jats:p>","DOI":"10.1042\/bj20110362","type":"journal-article","created":{"date-parts":[[2011,8,12]],"date-time":"2011-08-12T13:30:43Z","timestamp":1313155843000},"page":"229-244","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities"],"prefix":"10.1042","volume":"438","author":[{"given":"Lyn-Marie","family":"Birkholtz","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marni","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jandeli","family":"Niemand","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham\u00a0I.","family":"Louw","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, Lund University, S-221 84 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"Heby","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Ume\u00e5 University, S-901 87 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2011,8,12]]},"reference":[{"key":"2021112214524804000_B1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrc1454","article-title":"Polyamines and cancer: old molecules, new understanding","volume":"4","author":"Gerner","year":"2004","journal-title":"Nat. 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