{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:25:00Z","timestamp":1789899900011,"version":"4.0.1"},"reference-count":66,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,8,15]]},"abstract":"<jats:p>Gene expression during oocyte maturation and early embryogenesis up to zygotic genome activation requires translational activation of maternally-derived mRNAs. EPAB [embryonic poly(A)-binding protein] is the predominant poly(A)-binding protein during this period in Xenopus, mouse and human. In Xenopus oocytes, ePAB stabilizes maternal mRNAs and promotes their translation. To assess the role of EPAB in mammalian reproduction, we generated Epab-knockout mice. Although Epab\u2212\/\u2212 males and Epab+\/\u2212 of both sexes were fertile, Epab\u2212\/\u2212 female mice were infertile, and could not generate embryos or mature oocytes in vivo or in vitro. Epab\u2212\/\u2212 oocytes failed to achieve translational activation of maternally-stored mRNAs upon stimulation of oocyte maturation, including Ccnb1 (cyclin B1) and Dazl (deleted in azoospermia-like) mRNAs. Microinjection of Epab mRNA into Epab\u2212\/\u2212 germinal vesicle stage oocytes did not rescue maturation, suggesting that EPAB is also required for earlier stages of oogenesis. In addition, late antral follicles in the ovaries of Epab\u2212\/\u2212 mice exhibited impaired cumulus expansion, and a 8-fold decrease in ovulation, associated with a significant down-regulation of mRNAs encoding the EGF (epidermal growth factor)-like growth factors Areg (amphiregulin), Ereg (epiregulin) and Btc (betacellulin), and their downstream regulators, Ptgs2 (prostaglandin synthase 2), Has2 (hyaluronan synthase 2) and Tnfaip6 (tumour necrosis factor \u03b1-induced protein 6). The findings from the present study indicate that EPAB is necessary for oogenesis, folliculogenesis and female fertility in mice.<\/jats:p>","DOI":"10.1042\/bj20120467","type":"journal-article","created":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T08:34:19Z","timestamp":1338194059000},"page":"47-58","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice"],"prefix":"10.1042","volume":"446","author":[{"given":"Ozlem","family":"Guzeloglu-Kayisli","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 310 Cedar Street, LSOG 304D, New Haven, CT 06520, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u00a0D.","family":"Lalioti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 310 Cedar Street, LSOG 304D, New Haven, CT 06520, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulya","family":"Aydiner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 310 Cedar Street, LSOG 304D, New Haven, CT 06520, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Sasson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 310 Cedar Street, LSOG 304D, New Haven, CT 06520, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orkan","family":"Ilbay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 310 Cedar Street, LSOG 304D, New Haven, CT 06520, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denny","family":"Sakkas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 310 Cedar Street, LSOG 304D, New Haven, CT 06520, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie\u00a0M.","family":"Lowther","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, UConn Health Center, 263 Farmington Ave, Farmington, CT 06030, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa\u00a0M.","family":"Mehlmann","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, UConn Health Center, 263 Farmington Ave, Farmington, CT 06030, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Seli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 310 Cedar Street, LSOG 304D, New Haven, CT 06520, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2012,7,27]]},"reference":[{"key":"2021112215335313500_B1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/sedb.1994.1007","article-title":"Oocyte-somatic cell communication in the ovarian follicles of mammals","volume":"5","author":"Eppig","year":"1994","journal-title":"Semin. 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