{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:19:10Z","timestamp":1772828350653,"version":"3.50.1"},"reference-count":30,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"abstract":"<jats:p>Hv channels (voltage-gated proton channels) are expressed in blood cells, microglia and some types of epithelial cells. In neutrophils Hv channels regulate the production of reactive oxygen species through regulation of membrane potential and intracellular pH. Hv channels have also been suggested to play a role in sperm physiology in the human. However, the functions of the Hv channel at the whole-body level are not fully understood. In the present paper we show that Hvcn1 (voltage-gated hydrogen channel 1)-knockout mice show splenomegaly, autoantibodies and nephritis, that are reminiscent of human autoimmune diseases phenotypes. The number of activated T-cells was larger in Hvcn1-deficient mice than in the wild-type mice. Upon viral infection this was remarkably enhanced in Hvcn1-deficient mice. The production of superoxide anion in T-cells upon stimulation with PMA was significantly attenuated in the Hvcn1-deficient mice. These results suggest that Hv channels regulate T-cell homoeostasis in\u00a0vivo.<\/jats:p>","DOI":"10.1042\/bj20121188","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T09:48:35Z","timestamp":1355392115000},"page":"295-301","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Autoimmune disorder phenotypes in <i>Hvcn1<\/i>-deficient mice"],"prefix":"10.1042","volume":"450","author":[{"given":"Mari","family":"Sasaki","sequence":"first","affiliation":[{"name":"Laboratory of Integrative Physiology, Department of Physiology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan"},{"name":"Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan"},{"name":"Department of Molecular Medicine for Pathogenesis, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Tojo","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Okochi","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Physiology, Department of Physiology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Miyawaki","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Physiology, Department of Physiology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kamimura","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan"},{"name":"Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan"},{"name":"Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Okamura","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Physiology, Department of Physiology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan"},{"name":"Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2013,2,15]]},"reference":[{"key":"2021112215373599400_B1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/299826a0","article-title":"Hydrogen ion currents and intracellular pH in depolarized voltage-clamped snail neurones","volume":"299","author":"Thomas","year":"1982","journal-title":"Nature"},{"key":"2021112215373599400_B2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1152\/physrev.00028.2002","article-title":"Voltage-gated proton channels and other proton transfer pathways","volume":"83","author":"Decoursey","year":"2003","journal-title":"Physiol. 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