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Although many studies have investigated the regulation of Wnt\/\u03b2-catenin signalling, our knowledge remains insufficient due to the complexity and diversity of Wnt signalling. It is generally accepted that the identification of novel regulators and their functions is a prerequisite to fully elucidating the regulation of Wnt\/\u03b2-catenin signalling. Recently, several novel modulators of Wnt signalling have been determined through multiple genetic and proteomic approaches. In the present review, we discuss the mechanistic regulation of Wnt\/\u03b2-catenin signalling by focusing on the roles of these novel regulators.<\/jats:p>","DOI":"10.1042\/bj20121284","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T12:56:56Z","timestamp":1359032216000},"page":"9-21","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":282,"title":["Wnt\/\u03b2-catenin signalling: from plasma membrane to nucleus"],"prefix":"10.1042","volume":"450","author":[{"given":"Wantae","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Life Science, The University of Seoul, 90 Jeonnong-dong, Dongdaemun-gu, Seoul 130-743, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minseong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Science, The University of Seoul, 90 Jeonnong-dong, Dongdaemun-gu, Seoul 130-743, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eek-hoon","family":"Jho","sequence":"additional","affiliation":[{"name":"Department of Life Science, The University of Seoul, 90 Jeonnong-dong, Dongdaemun-gu, Seoul 130-743, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"2021112215461662900_B1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1056\/NEJMcibr055457","article-title":"Colon cancer: understanding how NSAIDs work","volume":"354","author":"Clevers","year":"2006","journal-title":"N. 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