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In the present study, we show that mRNAs encoding some structural and regulatory components of the WAVE [WASP (Wiskott\u2013Aldrich syndrome protein) verprolin homologous] complex are localized to the leading edge of the cell and associated with sites of active translation. Furthermore, we demonstrate that steady-state levels of ArpC2 and Rac1 proteins increase at the leading edge during cell spreading, suggesting that localized protein synthesis has a pivotal role in controlling cell spreading and migration.<\/jats:p>","DOI":"10.1042\/bj20121803","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T10:42:26Z","timestamp":1362566546000},"page":"45-55","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["mRNA encoding WAVE\u2013Arp2\/3-associated proteins is co-localized with foci of active protein synthesis at the leading edge of MRC5 fibroblasts during cell migration"],"prefix":"10.1042","volume":"452","author":[{"given":"Mark","family":"Willett","sequence":"first","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QG, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Brocard","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QG, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary\u00a0J.","family":"Pollard","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QG, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon\u00a0J.","family":"Morley","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QG, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"2021112215381224700_B1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrc1877","article-title":"Fibroblasts in cancer","volume":"6","author":"Kalluri","year":"2006","journal-title":"Nat. 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