{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:26:10Z","timestamp":1771867570023,"version":"3.50.1"},"reference-count":48,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,8,15]]},"abstract":"<jats:p>TM4SF5 (transmembrane 4\u00a0L six family member 5) is involved in EMT (epithelial\u2013mesenchymal transition) for liver fibrosis and cancer metastasis; however, the function(s) of TM4SF5 during embryogenesis remains unknown. In the present study the effects of TM4SF5 on embryogenesis of zebrafish were investigated. tm4sf5 mRNA was expressed in the posterior somites during somitogenesis and in whole myotome 1 dpf (day post-fertilization). tm4sf5 suppression impaired development of the trunk with aberrant morphology of muscle fibres and altered expression of integrin \u03b15. The arrangement and adhesion of muscle cells were abnormally disorganized in tm4sf5 morphants with reduced muscle fibre masses, where integrin \u03b15-related signalling molecules, including fibronectin, FAK (focal adhesion kinase), vinculin and actin were aberrantly localized, compared with those in control fish. Aberrant muscle developments in tm4sf5 morphants were recovered by additional tm4sf5 or integrin \u03b15 mRNA injection. Such a role for TM4SF5 was observed in the differentiation of C2C12 mouse myoblast cells to multinuclear muscle cells. Taken together, the results show that TM4SF5 controls muscle differentiation via co-operation with integrin \u03b15-related signalling.<\/jats:p>","DOI":"10.1042\/bj20140177","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T09:04:25Z","timestamp":1401959065000},"page":"89-101","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["TM4SF5 suppression disturbs integrin \u03b15-related signalling and muscle development in zebrafish"],"prefix":"10.1042","volume":"462","author":[{"given":"Yoon-Ju","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of 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