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First, we summarize the mechanisms governing flaviviral replication and the central role of conserved RNA elements and viral protein\u2013RNA interactions in RNA synthesis, translation and packaging. Secondly, we focus on how host RNA-binding proteins both benefit and inhibit flaviviral replication at different stages of their life cycle in mammalian hosts. Thirdly, we cover recent studies on viral non-coding RNAs produced in flavivirus-infected cells and how these RNAs affect various aspects of cellular RNA metabolism. Together, the article puts into perspective the central role of flaviviral RNAs in modulating both viral and cellular functions.<\/jats:p>","DOI":"10.1042\/bj20140456","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T14:21:51Z","timestamp":1407421311000},"page":"215-230","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Flaviviral RNAs: weapons and targets in the war between virus and host"],"prefix":"10.1042","volume":"462","author":[{"given":"Katell","family":"Bidet","sequence":"first","affiliation":[{"name":"Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857"},{"name":"NUS Graduate School for Integrative Sciences and Engineering, 28 Medical Drive, Singapore 117456"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano\u00a0A.","family":"Garcia-Blanco","sequence":"additional","affiliation":[{"name":"Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857"},{"name":"NUS Graduate School for Integrative Sciences and Engineering, 28 Medical Drive, Singapore 117456"},{"name":"Center for RNA Biology, Duke University Medical Center, 213 Research Drive, Durham, NC 27710, U.S.A."},{"name":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, 213 Research Drive, Durham, NC 27710, U.S.A."},{"name":"Department of Medicine, Duke University Medical Center, 213 Research Drive, Durham, NC 27710, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"2021112216052709200_B1","first-page":"1101","article-title":"Flaviviridae: the viruses and their replication","volume-title":"Fields Virology","author":"Lindenbach","year":"2007"},{"key":"2021112216052709200_B2","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.chom.2009.04.001","article-title":"Pathogenesis of flavivirus infections: using and abusing the host cell","volume":"5","author":"Fernandez-Garcia","year":"2009","journal-title":"Cell Host Microbe"},{"key":"2021112216052709200_B3","first-page":"723","article-title":"Regulation of flavivirus RNA synthesis and capping. 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