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The Glc7\u2013Reg1 complex takes part in the regulation of the yeast AMP-activated serine\/threonine protein kinase Snf1\u00a0in response to glucose. We demonstrate in the present study that the observed phenotypes of reg1 mutant cells are attributable to the inappropriate activation of Snf1. Indeed, growth in the presence of limited concentrations of glucose, where Snf1 is active, or expression of active forms of Snf1\u00a0in a wild-type strain increased the sensitivity to the UPR-inducer tunicamycin. Furthermore, reg1 mutant cells showed a sustained HAC1 mRNA splicing and KAR2 mRNA levels during the recovery phase of the UPR, and dysregulation of the Ire1-oligomeric equilibrium. Finally, overexpression of protein phosphatases Ptc2 and Ptc3 alleviated the growth defect of reg1 cells under endoplasmic reticulum (ER) stress conditions. Altogether, our results reveal that Snf1 plays an important role in the attenuation of the UPR, as well as identifying the protein kinase and its effectors as possible pharmacological targets for human diseases that are associated with insufficient UPR activation.<\/jats:p>","DOI":"10.1042\/bj20140734","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T16:53:46Z","timestamp":1425401626000},"page":"33-47","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in <i>Saccharomyces cerevisiae<\/i>"],"prefix":"10.1042","volume":"468","author":[{"given":"Jofre","family":"Ferrer-Dalmau","sequence":"first","affiliation":[{"name":"Institut de Biotecnologia i Biomedicina and Departament de Bioqu\u00edmica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Randez-Gil","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, Instituto de Agroqu\u00edmica y Tecnolog\u00eda de los Alimentos, Consejo Superior de Investigaciones Cient\u00edficas, 46980 Paterna, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Marquina","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i Biomedicina and Departament de Bioqu\u00edmica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9\u00a0A.","family":"Prieto","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, Instituto de Agroqu\u00edmica y Tecnolog\u00eda de los Alimentos, Consejo Superior de Investigaciones Cient\u00edficas, 46980 Paterna, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Casamayor","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i Biomedicina and Departament de Bioqu\u00edmica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2015,5,5]]},"reference":[{"key":"2021112216180693900_B1","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.tcb.2013.06.005","article-title":"IRE1: ER stress sensor and cell fate executor","volume":"23","author":"Chen","year":"2013","journal-title":"Trends Cell Biol."},{"key":"2021112216180693900_B2","doi-asserted-by":"publisher","first-page":"a013359","DOI":"10.1101\/cshperspect.a013359","article-title":"N-linked protein glycosylation in the endoplasmic reticulum","volume":"5","author":"Breitling","year":"2013","journal-title":"Cold Spring Harb. 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