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In the present paper, we show that in muscle-specific raptor knockout (RamKO), the bulk of glycogen phosphorylase (GP) is mainly associated in its cAMP-non-stimulated form with sarcoplasmic reticulum (SR) membranes. In addition, 3[H]\u2013ryanodine and 3[H]\u2013PN200-110 equilibrium binding show a ryanodine to dihydropyridine receptors (DHPRs) ratio of 0.79 and 1.35 for wild-type (WT) and raptor KO skeletal muscle membranes respectively. Peak amplitude and time to peak of the global calcium transients evoked by supramaximal field stimulation were not different between WT and raptor KO. However, the increase in the voltage sensor-uncoupled RyRs leads to an increase of both frequency and mass of elementary calcium release events (ECRE) induced by hyper-osmotic shock in flexor digitorum brevis (FDB) fibres from raptor KO. The present study shows that the protein composition and function of the molecular machinery involved in skeletal muscle excitation\u2013contraction (E\u2013C) coupling is affected by mTORC1 signalling.<\/jats:p>","DOI":"10.1042\/bj20140935","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T09:24:00Z","timestamp":1417425840000},"page":"123-135","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation\u2013contraction coupling supramolecular complex"],"prefix":"10.1042","volume":"466","author":[{"given":"Rub\u00e9n\u00a0J.","family":"Lopez","sequence":"first","affiliation":[{"name":"Departments of Anesthesia and of Biomedicine, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Mosca","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and of Biomedicine, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland"},{"name":"Department of Life Sciences, General Pathology section, University of Ferrara, Via Borsari 46, 44100 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Treves","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and of Biomedicine, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland"},{"name":"Department of Life Sciences, General Pathology section, University of Ferrara, Via Borsari 46, 44100 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Maj","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and of Biomedicine, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leda","family":"Bergamelli","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, General Pathology section, University of Ferrara, Via Borsari 46, 44100 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan\u00a0C.","family":"Calderon","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda Celular, Centro de Biof\u00edsica y Bioqu\u00edmica, Instituto Venezolano de Investigaciones Cient\u00edficas (IVIC), Apartado 20632, 1020A Caracas, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u00a0Florian","family":"Bentzinger","sequence":"additional","affiliation":[{"name":"Biozentrum, University of Basel, CH-4056 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaas","family":"Romanino","sequence":"additional","affiliation":[{"name":"Biozentrum, University of Basel, CH-4056 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael\u00a0N.","family":"Hall","sequence":"additional","affiliation":[{"name":"Biozentrum, University of Basel, CH-4056 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus\u00a0A.","family":"R\u00fcegg","sequence":"additional","affiliation":[{"name":"Biozentrum, University of Basel, CH-4056 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo","family":"Delbono","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Caputo","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda Celular, Centro de Biof\u00edsica y Bioqu\u00edmica, Instituto Venezolano de Investigaciones Cient\u00edficas (IVIC), Apartado 20632, 1020A Caracas, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Zorzato","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and of Biomedicine, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland"},{"name":"Department of Life Sciences, General Pathology section, University of Ferrara, Via Borsari 46, 44100 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2015,2,6]]},"reference":[{"key":"2021112216132923200_B1","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1016\/j.biocel.2006.02.013","article-title":"The TOR signalling network from yeast to man","volume":"38","author":"De Virgilio","year":"2006","journal-title":"Int. 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