{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:57:53Z","timestamp":1790420273782,"version":"4.1.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,3,1]]},"abstract":"<jats:p>Mice with hereditary kyphoscoliosis (ky\/ky) develop intervertebral-disc degeneration at the cervico-thoracic junction. Disc proteoglycans were investigated to determine whether changes in synthesis or structure were associated with this. Elevated 35S-proteoglycan synthesis was found in one or more cervico-thoracic discs in 80-day-old ky\/ky mice. The hydrodynamic size and aggregation properties of ky\/ky-mouse disc 35S-proteoglycans extracted with 4 M-guanidinium chloride were normal. Increased proportions of small 35S-proteoglycans were extracted with 0.5 M-guanidinium chloride from discs of normal and ky\/ky mice with increasing age.<\/jats:p>","DOI":"10.1042\/bj2340475","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T20:52:56Z","timestamp":1439239976000},"page":"475-479","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Changes in mouse intervertebral-disc proteoglycan synthesis with age. Hereditary kyphoscoliosis is associated with elevated synthesis"],"prefix":"10.1042","volume":"234","author":[{"given":"G","family":"Venn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/234\/2\/475\/586641\/bj2340475.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/234\/2\/475\/586641\/bj2340475.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T15:52:42Z","timestamp":1637855562000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/234\/2\/475\/21851\/Changes-in-mouse-intervertebral-disc-proteoglycan"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj2340475","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,3,1]]}}}