{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:35:29Z","timestamp":1770986129900,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,7,15]]},"abstract":"<jats:p>Attack by .OH radicals, generated by a Fenton system, upon salicylate produces 2,3-dihydroxybenzoate and 2,5-dihydroxybenzoate as major products and catechol as a minor product. H.p.l.c. separation combined with electrochemical detection was used to identify and quantify 2,3-dihydroxybenzoate and 2,5-dihydroxybenzoate in human plasma and synovial fluid. We propose that conversion of salicylate into 2,3-dihydroxybenzoate, or of other aromatic compounds into specific hydroxylated products, may be a useful assay for .OH formation in the human body.<\/jats:p>","DOI":"10.1042\/bj2370499","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T20:54:03Z","timestamp":1439240043000},"page":"499-504","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":319,"title":["Aromatic hydroxylation as a potential measure of hydroxyl-radical formation <i>in vivo<\/i>. Identification of hydroxylated derivatives of salicylate in human body fluids"],"prefix":"10.1042","volume":"237","author":[{"given":"M","family":"Grootveld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Halliwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/237\/2\/499\/587449\/bj2370499.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/237\/2\/499\/587449\/bj2370499.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T16:00:02Z","timestamp":1637856002000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/237\/2\/499\/21940\/Aromatic-hydroxylation-as-a-potential-measure-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7,15]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,7,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj2370499","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7,15]]}}}