{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T12:54:58Z","timestamp":1762520098791},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,12,15]]},"abstract":"<jats:p>Cu2Zn2-superoxide dismutase (CuZn-SOD) was purified from chicken liver. The liver enzyme had a subunit Mr of 16900 and contained equimolar amounts of copper and zinc [0.26% (w\/w) for each]. Aortic CuZn-SOD had the same Mr as estimated by gel filtration and cross-reacted with antibodies to the liver enzyme. Both enzymes were inhibited by 1.0 mM-NaCN. Within 24-72 h after hatching, total SOD activity in aorta rose 3-fold over the day-1 level and stayed elevated for 10 days. With low dietary copper, the total SOD activity rose as before, but then decayed progressively to non-detectable levels in 10 days. Both the cyanide-sensitive (CuZn-SOD) and insensitive (mangano-SOD) activities fell, but not at the same rate. When the 10-day-old deficient chicks were injected with 0.5 mumol of CuSO4 intraperitoneally, SOD activity in aorta was restored to control levels in about 8 h. Despite non-measurable SOD activity in aorta, extracts from the 15-day-old-deficient-chick tissue contained as much, or slightly more, immunoreactive CuZn-SOD protein as age-matched control tissue. The data show clearly that dietary copper regulates SOD activity in the aortas of young developing animals. They further suggest that a copper deficiency suppresses CuZn-SOD activity without inhibiting synthesis or accumulation of the CuZn protein in this tissue.<\/jats:p>","DOI":"10.1042\/bj2480663","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:09:18Z","timestamp":1439240958000},"page":"663-668","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Regulation of aortic CuZn-superoxide dismutase with copper. Effects <i>in vivo<\/i>"],"prefix":"10.1042","volume":"248","author":[{"given":"C T","family":"Dameron","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics and the Texas Agricultural Experiment Station, Texas A & M University, College Station, TX 77843-2128, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E D","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics and the Texas Agricultural Experiment Station, Texas A & M University, College Station, TX 77843-2128, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/248\/3\/663\/592957\/bj2480663.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/248\/3\/663\/592957\/bj2480663.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T18:09:09Z","timestamp":1637863749000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/248\/3\/663\/24522\/Regulation-of-aortic-CuZn-superoxide-dismutase"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,12,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,12,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj2480663","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,12,15]]}}}