{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:46:47Z","timestamp":1756190807009},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,9,1]]},"abstract":"<jats:p>Rats were maintained on a riboflavin-deficient diet or on a diet containing clofibrate (0.5%, w\/w). The activities of the mitochondrial FAD-dependent straight-chain acyl-CoA dehydrogenases (butyryl-CoA, octanoyl-CoA and palmitoyl-CoA) and the branched-chain acyl-CoA dehydrogenases (isovaleryl-CoA and isobutyryl-CoA) involved in the degradation of branched-chain acyl-CoA esters derived from branched-chain amino acids were assayed in liver mitochondrial extracts prepared in the absence and presence of exogenous FAD. These activities were low in livers from riboflavin-deficient rats (11, 28, 16, 6 and less than 2% of controls respectively) when prepared in the absence of exogenous FAD, and were not restored to control values when prepared in 25 microM-FAD (29, 47, 28, 7 and 17%). Clofibrate feeding increased the activities of butyryl-CoA, octanoyl-CoA and palmitoyl-CoA dehydrogenases (by 48, 116 and 98% of controls respectively), but not, by contrast, the activities of isovaleryl-CoA and isobutyryl-CoA dehydrogenases (62 and 102% of controls respectively). The mitochondrial fractions from riboflavin-deficient and from clofibrate-fed rats oxidized palmitoylcarnitine in State 3 at rates of 32 and 163% respectively of those from control rats.<\/jats:p>","DOI":"10.1042\/bj2540477","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:11:55Z","timestamp":1439241115000},"page":"477-481","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of riboflavin deficiency and clofibrate treatment on the five acyl-CoA dehydrogenases in rat liver mitochondria"],"prefix":"10.1042","volume":"254","author":[{"given":"K","family":"Veitch","sequence":"first","affiliation":[{"name":"Laboratoire de Chimie Physiologique, I.C.P. and Universit\u00e9 Catholique de Louvain, avenue Hippocrate 75, B-1200 Brussels, Belgium"},{"name":"Department of Pharmacological Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Draye","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Physiologique, I.C.P. and Universit\u00e9 Catholique de Louvain, avenue Hippocrate 75, B-1200 Brussels, Belgium"},{"name":"Department of Pediatric Neurology, Universit\u00e9 Catholique de Louvain, avenue Mounier 10, B-1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Van Hoof","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Physiologique, I.C.P. and Universit\u00e9 Catholique de Louvain, avenue Hippocrate 75, B-1200 Brussels, Belgium"},{"name":"Department of Pediatric Neurology, Universit\u00e9 Catholique de Louvain, avenue Mounier 10, B-1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H S A","family":"Sherratt","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/254\/2\/477\/627987\/bj2540477.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/254\/2\/477\/627987\/bj2540477.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T18:03:38Z","timestamp":1637863418000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/254\/2\/477\/24146\/Effects-of-riboflavin-deficiency-and-clofibrate"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj2540477","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9,1]]}}}