{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:25:40Z","timestamp":1778869540030,"version":"3.51.4"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,6,1]]},"abstract":"<jats:p>The respiratory properties of mitochondria isolated from the livers of rats infected with the parasite Fasciola hepatica were examined. Oligomycin-sensitive ATPase activity was also examined during the acute stage (2-4 weeks post-infection). At 2,4 and 6 weeks post-infection, mitochondrial respiration in vitro (supported by site I and site II substrates) was completely uncoupled. Limited respiratory control had returned by 11 weeks post-infection, but complete recovery was not observed even at 21 weeks post-infection. At 4 weeks post-infection, uncoupled respiration (from all three energy-conserving sites) was also markedly attenuated (to the greatest extent with NADH-linked substrate). Except for pyruvate-supported respiration, this attenuation was not apparent at any other stage of the infection. The attenuation of pyruvate-supported respiration declined, but was still present, at 6 weeks post-infection. In addition to these perturbations in mitochondrial respiratory properties, mitochondrial ATPase activity at 4 weeks post-infection was insensitive to oligomycin, indicating a change in the structural integrity of the ATPase complex.<\/jats:p>","DOI":"10.1042\/bj2600517","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:13:42Z","timestamp":1439241222000},"page":"517-523","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Aberrant energy-linked reactions in mitochondria isolated from the livers of rats infected with the liver fluke <i>Fasciola hepatica<\/i>"],"prefix":"10.1042","volume":"260","author":[{"given":"C J","family":"Rule","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, Australian National University, Canberra ACT 2601, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Behm","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, Australian National University, Canberra ACT 2601, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F L","family":"Bygrave","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, Australian National University, Canberra ACT 2601, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/260\/2\/517\/595268\/bj2600517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/260\/2\/517\/595268\/bj2600517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T18:14:07Z","timestamp":1637864047000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/260\/2\/517\/24952\/Aberrant-energy-linked-reactions-in-mitochondria"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj2600517","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6,1]]}}}