{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:39:14Z","timestamp":1790642354423,"version":"4.1.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,12,15]]},"abstract":"<jats:p>The rat carotid body tissue reveals a photometrically measurable haem signal with absorbance maxima at 560 nm, 518 nm and 425 nm, suggesting the presence of a b-type cytochrome; this was confirmed by pyridine haemochrome and CO spectra. The quantity of cytochrome b was estimated to be 310 pmol.mg of protein-1. This haem is capable of H2O2 formation, which can be inhibited by 10 microM-diphenyliodonium (DPI). The hypoxia-induced increase in nervous chemoreceptor discharge and the reduction of FAD and NAD(P)+ were also inhibited by DPI (10 microM). These results suggest that an oxidase such as the NAD(P)H oxidase of neutrophils may act as a pO2 sensor protein in the rat carotid body, probably inducing the pO2 chemoreceptor process by H2O2 formation.<\/jats:p>","DOI":"10.1042\/bj2720743","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:18:57Z","timestamp":1439241537000},"page":"743-747","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":173,"title":["Involvement of an NAD(P)H oxidase as a <i>p<\/i>O2 sensor protein in the rat carotid body"],"prefix":"10.1042","volume":"272","author":[{"given":"A R","family":"Cross","sequence":"first","affiliation":[{"name":"Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O T G","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Delpiano","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Systemphysiologie, Rheinlanddamm 201, D-4600 Dortmund 1, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hentschel","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Systemphysiologie, Rheinlanddamm 201, D-4600 Dortmund 1, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Acker","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Systemphysiologie, Rheinlanddamm 201, D-4600 Dortmund 1, Federal Republic of Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/272\/3\/743\/601838\/bj2720743.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/272\/3\/743\/601838\/bj2720743.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T18:41:12Z","timestamp":1637865672000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/272\/3\/743\/26391\/Involvement-of-an-NAD-P-H-oxidase-as-a-pO2-sensor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,12,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj2720743","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12,15]]}}}