{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:28:14Z","timestamp":1791649694622,"version":"4.3.4"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,7,15]]},"abstract":"<jats:p>The acute-phase response to tissue injury and inflammation is accompanied by a dramatic increase in the hepatic synthesis of plasma proteins known as acute-phase reactants (APRs). This response is mediated by cytokines produced in part by activated macrophages at the site of inflammation; glucocorticoids have also been implicated as playing a regulatory role. The effects of the cytokines interleukin (IL)-1 beta and -6, alone or in combination, and in the absence or presence of the synthetic glucocorticoid dexamethasone, on the levels of APR mRNAs in the human hepatoma cell line PLC\/PRF\/5 were analysed. The accumulation of APR mRNAs [the complement components C3, factor B and Cl inhibitor; the major APRs C-reactive protein (CRP) and serum amyloid A protein and the CRP analogue serum amyloid P protein] was determined in dose-response and time-course studies. The APRs differed from each other in their responses to IL-1 beta alone, IL-6 alone, and IL-1 beta plus IL-6. Dexamethasone enhanced the cytokine-driven induction of a subset of APR mRNAs. These studies detail the heterogeneity of the \u2018in vitro\u2019 acute-phase response to defined mediators.<\/jats:p>","DOI":"10.1042\/bj2770477","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:22:29Z","timestamp":1439241749000},"page":"477-482","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Heterogeneous modulation of acute-phase-reactant mRNA levels by interleukin-1 <i>\u03b2<\/i> and interleukin-6 in the human hepatoma cell line PLC\/PRF\/5"],"prefix":"10.1042","volume":"277","author":[{"given":"D M","family":"Steel","sequence":"first","affiliation":[{"name":"Division of Immunology, Children's Hospital, Boston, MA 02115, U.S.A."},{"name":"\u2020Center for Blood Research, Boston, MA 02115, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A S","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Division of Immunology, Children's Hospital, Boston, MA 02115, U.S.A."},{"name":"\u2020Center for Blood Research, Boston, MA 02115, U.S.A"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/277\/2\/477\/604172\/bj2770477.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/277\/2\/477\/604172\/bj2770477.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:58:32Z","timestamp":1637715512000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/277\/2\/477\/37048\/Heterogeneous-modulation-of-acute-phase-reactant"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7,15]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,7,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj2770477","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7,15]]}}}