{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T04:41:40Z","timestamp":1761021700858},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,3,1]]},"abstract":"<jats:p>Tissue from two patients with osteogenesis imperfecta suffering from a hyperplastic callus was studied. Although collagen type I from the compact bone and the skin and fibroblast cultures of these patients showed normal lysyl hydroxylation, collagen types I, II, III and V from the callus tissue were markedly overhydroxylated. Furthermore, the overhydroxylation of lysine residues covered almost equally the entire alpha 1 (I) collagen chain, as demonstrated by the analysis of individual CNBr-derived peptides. In addition, collagen type I was isolated from femoral compact bone of 33 individuals who died between the 16th week of gestational age and 22 years. Lysyl hydroxylation rapidly decreased in both collagen alpha 1 (I) and alpha 2 (I) chains during fetal development, and only little in the postnatal period. The transient increase in lysyl hydroxylation and the involvement of various collagen types in callus tissue argue for a regulatory mechanism that may operate in bone repair and during fetal development.<\/jats:p>","DOI":"10.1042\/bj2820313","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:25:44Z","timestamp":1439241944000},"page":"313-318","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Lysyl hydroxylation in collagens from hyperplastic callus and embryonic bones"],"prefix":"10.1042","volume":"282","author":[{"given":"H W","family":"Lehmann","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Medizinische Molekularbiologie, Ratzeburger Allee 160, D-2400 L\u00fcbeck, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bodo","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Molekularbiologie, Ratzeburger Allee 160, D-2400 L\u00fcbeck, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Frohn","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Molekularbiologie, Ratzeburger Allee 160, D-2400 L\u00fcbeck, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Nerlich","sequence":"additional","affiliation":[{"name":"Pathologisches Institut, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, D-8000 M\u00fcnchen, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Rimek","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Molekularbiologie, Ratzeburger Allee 160, D-2400 L\u00fcbeck, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Notbohm","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Molekularbiologie, Ratzeburger Allee 160, D-2400 L\u00fcbeck, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P K","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Molekularbiologie, Ratzeburger Allee 160, D-2400 L\u00fcbeck, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/282\/2\/313\/606561\/bj2820313.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/282\/2\/313\/606561\/bj2820313.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T21:48:43Z","timestamp":1637704123000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/282\/2\/313\/27762\/Lysyl-hydroxylation-in-collagens-from-hyperplastic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj2820313","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3,1]]}}}