{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:07:24Z","timestamp":1787771244229,"version":"build-2784847793"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,3,1]]},"abstract":"<jats:p>The action of Taiwan cobra (Naja naja atra) venom cardiotoxin on rabbit platelets at 37 degrees C was characterized by observing cytoskeletal alterations and cell lysis. At a concentration of 21.4 microM the toxin produced no cell lysis within 30 s, and less than 5% of the total lactate dehydrogenase activity of intact cells was detected in the suspending medium after the interaction had proceeded for 3 min. The extent of cell lysis was proportional to toxin concentration and interaction time. Before cell lysis, the toxin caused rapid incorporation of actin monomers into cross-linked actin filaments. The actin incorporation could be inhibited by either the presence of cytochalasin B or increased CaCl2 concentration in the suspending medium. However, addition of indomethacin did not influence the toxin-induced cytoskeletal change.<\/jats:p>","DOI":"10.1042\/bj2900591","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:31:17Z","timestamp":1439242277000},"page":"591-594","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Snake venom cardiotoxin can rapidly induce actin polymerization in intact platelets"],"prefix":"10.1042","volume":"290","author":[{"given":"R F","family":"Liou","sequence":"first","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, National Taiwan University, Taipei, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W C","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Biochemical Sciences, College of Sciences, National Taiwan University, Taipei, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S T","family":"Chu","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, National Taiwan University, Taipei, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y H","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, National Taiwan University, Taipei, Taiwan, Republic of China"},{"name":"Institute of Biochemical Sciences, College of Sciences, National Taiwan University, Taipei, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/290\/2\/591\/610188\/bj2900591.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/290\/2\/591\/610188\/bj2900591.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T17:58:16Z","timestamp":1637690296000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/290\/2\/591\/29403\/Snake-venom-cardiotoxin-can-rapidly-induce-actin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj2900591","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3,1]]}}}