{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:07:57Z","timestamp":1791130077164,"version":"4.1.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,3,15]]},"abstract":"<jats:p>The indolic hormone melatonin is produced by the pineal gland according to a daily rhythm. The terminal step of melatonin synthesis is catalysed by hydroxyindole O-methyltransferase (HIOMT, EC 2.1.1.4). Adaptation to constant light or darkness modifies HIOMT activity and concentration. Using a cDNA probe encoding HIOMT, we investigated the effect of environmental lighting on HIOMT gene expression in the chicken pineal gland. HIOMT mRNA levels increased by 100% in constant light as compared with constant darkness. In addition, the present study disclosed the existence of a day\/night rhythm of HIOMT gene transcription, with 3-fold higher mRNA levels at midday than at midnight. This transcriptional rhythm was not accompanied by day\/night changes in HIOMT concentration, probably due to a slow turnover of this protein. Unexpected darkness did not prevent the daytime rise in HIOMT mRNA levels, whereas unexpected light prevented the night-time fall in HIOMT mRNA levels. Together, the data would suggest that the day\/night rhythm of HIOMT gene transcription in the chicken pineal gland involves both a response to light and the activity of a biological oscillator.<\/jats:p>","DOI":"10.1042\/bj2900661","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:31:17Z","timestamp":1439242277000},"page":"661-664","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Transcriptional regulation of hydroxyindole <i>O<\/i>-methyltransferase in the chicken pineal gland: day\/night changes and long-term effects of light and darkness"],"prefix":"10.1042","volume":"290","author":[{"given":"M","family":"Bernard","sequence":"first","affiliation":[{"name":"Laboratoire de Neurobiologie et Neuroendocrinologie Cellulaires, URA CNRS 290."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Guerlotte","sequence":"additional","affiliation":[{"name":"Laboratoire de Neurobiologie et Neuroendocrinologie Cellulaires, URA CNRS 290."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cogne","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunologie Moleculaire, URA CNRS 1172, Universite de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Greve","sequence":"additional","affiliation":[{"name":"Laboratoire de Neurobiologie et Neuroendocrinologie Cellulaires, URA CNRS 290."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P","family":"Collin","sequence":"additional","affiliation":[{"name":"Laboratoire de Neurobiologie et Neuroendocrinologie Cellulaires, URA CNRS 290."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Voisin","sequence":"additional","affiliation":[{"name":"Laboratoire de Neurobiologie et Neuroendocrinologie Cellulaires, URA CNRS 290."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/290\/3\/661\/610112\/bj2900661.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/290\/3\/661\/610112\/bj2900661.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T22:01:59Z","timestamp":1637704919000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/290\/3\/661\/28391\/Transcriptional-regulation-of-hydroxyindole-O"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,3,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj2900661","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3,15]]}}}