{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:01:41Z","timestamp":1790258501013,"version":"4.1.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,5,1]]},"abstract":"<jats:p>The effects of graded doses of insulin-like growth factor-I (IGF-I) and two variants which bind poorly to IGF-binding proteins were investigated in 160 g streptozotocin-induced diabetic rats. The two variants were the truncated form, des(1-3)IGF-I, and another with arginine at residue 3 and an N-terminal extension, termed LR3-IGF-I. The peptides were infused via mini-osmotic pumps. Reference groups received either vehicle or insulin (30 i.u. per day). Treatment led to a marked dose-dependent increase in growth rate and nitrogen balance. The highest dose (695 micrograms\/day) of IGF-I increased body weight by 48.1 +\/- 1.7 g\/7 days, compared with 11.0 +\/- 2.8 g\/7 days for the vehicle-treated group. The two variants were 2.5-3 times more potent than IGF-I in restoring growth. The insulin-treated group gained more weight (64.5 +\/- 1.6 g\/7 days), but the added gain was fat (92.5 +\/- 4.8 g of fat\/kg carcass wet wt., compared with 32.2 +\/- 2.1 for all other groups) rather than protein. All peptides increased muscle protein-synthesis rates and RNA levels by up to 50%, with IGF-I the least potent. These high doses of IGFs did not decrease either the glucosuria or the daily excretion rate of N tau-methyl-histidine (N tau-MH). On the other hand, insulin treatment markedly decreased both glucosuria (from 82.7 +\/- 5.4 to 4.5 +\/- 3.3 mmol\/day) and N tau-MH excretion (from 9.3 +\/- 0.3 to 7.1 +\/- 0.4 mumol\/day per kg). This experiment shows that, although IGF-I and variants can restore growth in diabetic rats, other insulin-dependent metabolic processes in liver, muscle and adipose tissue are not restored.<\/jats:p>","DOI":"10.1042\/bj2910781","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:32:05Z","timestamp":1439242325000},"page":"781-786","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Insulin-like growth factor-I and more potent variants restore growth of diabetic rats without inducing all characteristic insulin effects"],"prefix":"10.1042","volume":"291","author":[{"given":"F M","family":"Tomas","sequence":"first","affiliation":[{"name":"Cooperative Research Centre for Tissue Growth and Repair, and CSIRO, Division of Human Nutrition, Adelaide, S.A. 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S E","family":"Knowles","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Tissue Growth and Repair, and CSIRO, Division of Human Nutrition, Adelaide, S.A. 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C","family":"Owens","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Tissue Growth and Repair, and CSIRO, Division of Human Nutrition, Adelaide, S.A. 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C S","family":"Chandler","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Tissue Growth and Repair, and CSIRO, Division of Human Nutrition, Adelaide, S.A. 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G L","family":"Francis","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Tissue Growth and Repair, and CSIRO, Division of Human Nutrition, Adelaide, S.A. 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F J","family":"Ballard","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Tissue Growth and Repair, and CSIRO, Division of Human Nutrition, Adelaide, S.A. 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/291\/3\/781\/610473\/bj2910781.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/291\/3\/781\/610473\/bj2910781.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T21:55:29Z","timestamp":1637704529000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/291\/3\/781\/28073\/Insulin-like-growth-factor-I-and-more-potent"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj2910781","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,5,1]]}}}