{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T18:42:40Z","timestamp":1648838560768},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,10,1]]},"abstract":"<jats:p>The capability of (4R)-4-(2,3,4,6,6a beta,7,8,9,9a alpha,9b beta-decahydro-6a beta-methyl-3-oxo-1H-cyclopental[f]quinolin-7 beta-yl)valeric acid (DCQVA), a catabolite of cholic acid produced by enterobacteria, to induce peroxisome proliferation in vivo and in vitro was studied. Rats given 0.3% DCQVA in the diet for 2 weeks showed marked increases in peroxisomal beta-oxidation, mitochondrial 2,4-dienoyl-CoA reductase and microsomal laurate omega-oxidation activities in the liver compared with control rats given the diet without DCQVA. Cultured rat hepatocytes treated with DCQVA for 72 h also exhibited greatly enhanced beta-oxidation activity. The increased activity was concentration-dependent and the effective concentrations were comparable with those of clofibric acid that produced the same degree of induction in the assay. The results demonstrate that DCQVA is a potent peroxisome proliferator that occurs naturally in rat intestine.<\/jats:p>","DOI":"10.1042\/bj2950217","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:35:01Z","timestamp":1439242501000},"page":"217-220","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Induction of peroxisomal <i>\u03b2<\/i>-oxidation by a microbial catabolite of cholic acid in rat liver and cultured rat hepatocytes"],"prefix":"10.1042","volume":"295","author":[{"given":"T","family":"Nishimaki-Mogami","sequence":"first","affiliation":[{"name":"National Institute of Hygienic Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Takahashi","sequence":"additional","affiliation":[{"name":"National Institute of Hygienic Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Toyoda","sequence":"additional","affiliation":[{"name":"National Institute of Hygienic Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Hayashi","sequence":"additional","affiliation":[{"name":"National Institute of Hygienic Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/295\/1\/217\/724487\/bj2950217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/295\/1\/217\/724487\/bj2950217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T22:24:02Z","timestamp":1637706242000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/295\/1\/217\/30549\/Induction-of-peroxisomal-oxidation-by-a-microbial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,10,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj2950217","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10,1]]}}}