{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:59:47Z","timestamp":1779343187657,"version":"3.51.4"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,9,15]]},"abstract":"<jats:p>We have isolated cDNA clones encoding an inositol 1,4,5-trisphosphate receptor type 1 (InsP3R1) from human uteri and a leukaemic cell line, HL-60. Northern-blot analysis showed that approx. 10 kb of InsP3R1 mRNA is expressed in human uteri, oviducts and HL-60 cells. The predicted amino acid sequence of human InsP3R1 (2695 amino acids) has 99% identity with that of the mouse SI-\/SII- splicing counterpart. Western-blot analysis with anti-(mouse InsP3R1) antibodies showed that InsP3R1 protein of human uteri and oviducts of approx 220 kDa is immunostained. Northern-blot analysis of HL-60 cell differentiation along the neutrophilic lineage induced by retinoic acid or dimethylsulphoxide showed an accompanying enhanced expression of InsP3R1 mRNA. Immunohistochemical analysis of the cerebella of spinocerebellar degeneration patients showed a variable loss of Purkinje cells with an altered pattern of immunostaining. The InsP3R1 gene (Insp3r1) was localized to the 3P25-26 region of human chromosome 3. The data presented here clearly show that InsP3R1 exists widely in human tissues and may play critical roles in various kinds of cellular functions.<\/jats:p>","DOI":"10.1042\/bj3020781","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:39:10Z","timestamp":1439242750000},"page":"781-790","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Human inositol 1,4,5-trisphosphate type-1 receptor, Ins<i>P<\/i>3R1: structure, function, regulation of expression and chromosomal localization"],"prefix":"10.1042","volume":"302","author":[{"given":"N","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Makino","sequence":"additional","affiliation":[{"name":"Minase Research Institute, Ono Pharmaceutical Co. Ltd., 3-1-1 Sakurai Shimamoto-cho, Mishima-gun, Osaka 618, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Clark","sequence":"additional","affiliation":[{"name":"The Division of Infectious Disease, College of Medicine, The University of Iowa, 200 Hawkins Drive, SW54 GH, Iowa City, IA 52242 U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D W","family":"Pearson","sequence":"additional","affiliation":[{"name":"The Division of Infectious Disease, College of Medicine, The University of Iowa, 200 Hawkins Drive, SW54 GH, Iowa City, IA 52242 U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M G","family":"Mattei","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche no. 242, Physiopathologie Chromosomique Hospital d'enfants, Groupe Hospitalier de la Timone, 13385 Marseille Cedex 5, France,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Gu\u00e9net","sequence":"additional","affiliation":[{"name":"Inst\u00edtut Pasteur, 28 Rue du Dr Roux, 75724 Paris Cedex 15, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Ohama","sequence":"additional","affiliation":[{"name":"The Division of Neuropathology, Institute of Neurological Sciences, Tottori University School of Medicine, 86 Nishimachi, Yonago, Tottori 683, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Miyawaki","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Furuichi","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"MIKOSHIBA","sequence":"additional","affiliation":[{"name":"Minase Research Institute, Ono Pharmaceutical Co. Ltd., 3-1-1 Sakurai Shimamoto-cho, Mishima-gun, Osaka 618, Japan"},{"name":"The Molecular Neurobiology Laboratory, The Institute of Physical and Chemical Research (RIKEN), Tsukuba Life Science Center, 3-1-1 Koyadai, Tsukuba-shi, Ibaragi 305, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/302\/3\/781\/615214\/bj3020781.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/302\/3\/781\/615214\/bj3020781.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T23:11:01Z","timestamp":1637709061000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/302\/3\/781\/31096\/Human-inositol-1-4-5-trisphosphate-type-1-receptor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,9,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj3020781","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,9,15]]}}}