{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:38:42Z","timestamp":1770701922400,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,12,1]]},"abstract":"<jats:p>The lethal factor of Bacillus anthracis is central to the pathogenesis of anthrax. Its mechanism of action is still unknown. Recently, on the basis of sequence similarities, we suggested that lethal factor might act similarly to leukotriene A4 hydrolase (LTA4), a bifunctional enzyme also endowed with a metallopeptidase activity. Here we show that some inhibitors of the LTA4 hydrolase and metallopeptidase activities of LTA4 hydrolase also affect the cytotoxicity of the anthrax lethal factor on macrophage cell lines, without interfering with the ability of the lethal factor to enter cells. These results support the proposal that anthrax lethal factor might display in the cytosol of intoxicated cells a peptidase activity similar to that of LTA4 hydrolase.<\/jats:p>","DOI":"10.1042\/bj3200687","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:51:59Z","timestamp":1439243519000},"page":"687-691","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The cytotoxic activity of <i>Bacillus anthracis<\/i> lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors"],"prefix":"10.1042","volume":"320","author":[{"given":"Armelle","family":"M\u00c9NARD","sequence":"first","affiliation":[{"name":"Centro CNR Biomembrane and Dipartimento di Scienze Biomediche, Universit\u00e0 di Padova, Via Trieste 75, 35121 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"PAPINI","sequence":"additional","affiliation":[{"name":"Centro CNR Biomembrane and Dipartimento di Scienze Biomediche, Universit\u00e0 di Padova, Via Trieste 75, 35121 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"MOCK","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire des Toxines (URA 1858, CNRS), Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"MONTECUCCO","sequence":"additional","affiliation":[{"name":"Centro CNR Biomembrane and Dipartimento di Scienze Biomediche, Universit\u00e0 di Padova, Via Trieste 75, 35121 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/320\/2\/687\/623045\/bj3200687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/320\/2\/687\/623045\/bj3200687.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T01:06:23Z","timestamp":1637715983000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/320\/2\/687\/37889\/The-cytotoxic-activity-of-Bacillus-anthracis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj3200687","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,12,1]]}}}