{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:22:47Z","timestamp":1761744167080},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,1,1]]},"abstract":"<jats:p>Apolipoproteins in cerebrospinal fluid (CSF) might have important functional roles in the pathophysiology of brain and lipid metabolism in the vascular component. The present study examined apolipoprotein A-I (apo-A-I) and apolipoprotein E (apo-E) levels in CSF and serum from poliovirus-infected macaques. Poliovirus-infected macaques developed motor deficits and were classified into three groups: (1) muscle weakness in one or both legs; (2) partial paralysis in one or both legs; (3) complete paralysis in one or both legs. No motor deficits were evident in the control or sham-treated macaques. Apo-A-I concentrations in CSF were markedly elevated in poliovirus-infected macaques with weakness, partial or complete paralysis, in comparison with either control or sham-treated animals, and were proportional to the severity of motor impairment. Apo-E concentrations in CSF were also significantly elevated in poliovirus-infected macaques with complete paralysis. The magnitude of increase in CSF apo-A-I or apo-E concentrations was also closely associated with the degree of histologic neurological damage and inflammation (lesion scores). However, no changes in serum apo-A-I and apo-E concentrations were observed in the poliovirus-infected macaques compared with control macaques. Furthermore there were no significant correlations apo-A-I or apo-E concentrations between serum and CSF. We hypothesize that the elevation of apo-A-I and apo-E concentrations after poliovirus infection is caused by immune stimulation within the central nervous system (CNS). Measures of CSF apo-A-I and apo-E levels might serve as a useful marker for the severity and\/or the range of CNS injury.<\/jats:p>","DOI":"10.1042\/bj3210145","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:52:36Z","timestamp":1439243556000},"page":"145-149","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Marked increases in concentrations of apolipoprotein in the cerebrospinal fluid of poliovirus-infected macaques: relations between apolipoprotein concentrations and severity of brain injury"],"prefix":"10.1042","volume":"321","author":[{"given":"Kuniaki","family":"SAITO","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Gifu University School of Medicine, Gifu 500, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"SEISHIMA","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Gifu University School of Medicine, Gifu 500, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvyn P.","family":"HEYES","sequence":"additional","affiliation":[{"name":"Laboratory of Neurotoxicology, National Institute of Mental Health, Bethesda, MD 20892, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"SONG","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Gifu University School of Medicine, Gifu 500, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suwako","family":"FUJIGAKI","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Gifu University School of Medicine, Gifu 500, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"MAEDA","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Gifu University School of Medicine, Gifu 500, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"VICKERS","sequence":"additional","affiliation":[{"name":"Pathobiology and Primatology Laboratory, Center for Biological Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"NOMA","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Gifu University School of Medicine, Gifu 500, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/321\/1\/145\/622277\/bj3210145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/321\/1\/145\/622277\/bj3210145.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:11:50Z","timestamp":1637712710000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/321\/1\/145\/32785\/Marked-increases-in-concentrations-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bj3210145","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1,1]]}}}