{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:07:33Z","timestamp":1776362853295,"version":"3.51.2"},"reference-count":69,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":2359,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:p>NCLs (neuronal ceroid lipofuscinoses) form a group of eight inherited autosomal recessive diseases characterized by the intralysosomal accumulation of autofluorescent pigments, called ceroids. Recent data suggest that the pathogenesis of NCL is associated with the appearance of fragmented mitochondria with altered functions. However, even if an impairement in the autophagic pathway has often been evoked, the molecular mechanisms leading to mitochondrial fragmentation in response to a lysosomal dysfunction are still poorly understood. In this study, we show that fibroblasts that are deficient for the TPP-1 (tripeptidyl peptidase-1), a lysosomal hydrolase encoded by the gene mutated in the LINCL (late infantile NCL, CLN2 form) also exhibit a fragmented mitochondrial network. This morphological alteration is accompanied by an increase in the expression of the protein BNIP3 (Bcl2\/adenovirus E1B 19\u00a0kDa interacting protein 3) as well as a decrease in the abundance of mitofusins 1 and 2, two proteins involved in mitochondrial fusion. Using RNAi (RNA interference) and quantitative analysis of the mitochondrial morphology, we show that the inhibition of BNIP3 expression does not result in an increase in the reticulation of the mitochondrial population in LINCL cells. However, this protein seems to play a key role in cell response to mitochondrial oxidative stress as it sensitizes mitochondria to antimycin A-induced fragmentation. To our knowledge, our results bring the first evidence of a mechanism that links TPP-1 deficiency and oxidative stress-induced changes in mitochondrial morphology.<\/jats:p>","DOI":"10.1042\/bsr20120104","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T09:55:22Z","timestamp":1355910922000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Different molecular mechanisms involved in spontaneous and oxidative stress-induced mitochondrial fragmentation in tripeptidyl peptidase-1 (TPP-1)-deficient fibroblasts"],"prefix":"10.1042","volume":"33","author":[{"given":"Guillaume","family":"Van Beersel","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry and Cellular Biology (URBC), NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur (FUNDP), rue de Bruxelles, 61, 5000 Namur, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane","family":"Tihon","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Cellular Biology (URBC), NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur (FUNDP), rue de Bruxelles, 61, 5000 Namur, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Demine","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Cellular Biology (URBC), NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur (FUNDP), rue de Bruxelles, 61, 5000 Namur, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Hamer","sequence":"additional","affiliation":[{"name":"Unity of Research in Molecular Physiology (URPhyM), Laboratory of Physiological Chemistry, Namur Research Institute for LIfe Sciences (NARILIS), University of Namur (FUNDP), rue de Bruxelles, 61, 5000 Namur, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Jadot","sequence":"additional","affiliation":[{"name":"Unity of Research in Molecular Physiology (URPhyM), Laboratory of Physiological Chemistry, Namur Research Institute for LIfe Sciences (NARILIS), University of Namur (FUNDP), rue de Bruxelles, 61, 5000 Namur, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Arnould","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Cellular Biology (URBC), NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur (FUNDP), rue de Bruxelles, 61, 5000 Namur, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2013,2,7]]},"reference":[{"key":"2021111618233851400_B1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.bbamcr.2008.11.014","article-title":"Secondary lipid accumulation in lysosomal disease","volume":"1793","author":"Walkley","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111618233851400_B2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00018-010-0468-6","article-title":"Interactions of the proteins of neuronal ceroid lipofuscinosis: clues to function","volume":"68","author":"Getty","year":"2011","journal-title":"Cell Mol. Life Sci."},{"key":"2021111618233851400_B3","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1046\/j.1471-4159.1999.0730700.x","article-title":"Biochemical characterization of a lysosomal protease deficient in classical late infantile neuronal ceroid lipofuscinosis (LINCL) and development of an enzyme-based assay for diagnosis and exclusion of LINCL in human specimens and animal models","volume":"73","author":"Sohar","year":"1999","journal-title":"J. Neurochem."},{"key":"2021111618233851400_B4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1042\/bj20020467","article-title":"Lysosomal degradation of cholecystokinin-(29\u201333)-amide in mouse brain is dependent on tripeptidyl peptidase-I: implications for the degradation and storage of peptides in classical late-infantile neuronal ceroid lipofuscinosis","volume":"366","author":"Bernardini","year":"2002","journal-title":"Biochem. J."},{"key":"2021111618233851400_B5","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1046\/j.1471-4159.1999.0722573.x","article-title":"A lysosomal proteinase, the late infantile neuronal ceroid lipofuscinosis gene (CLN2) product, is essential for degradation of a hydrophobic protein, the subunit c of ATP synthase","volume":"72","author":"Ezaki","year":"1999","journal-title":"J. Neurochem."},{"key":"2021111618233851400_B6","doi-asserted-by":"crossref","first-page":"11507","DOI":"10.1074\/jbc.M807151200","article-title":"Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner","volume":"284","author":"Autefage","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2021111618233851400_B7","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1126\/science.277.5333.1802","article-title":"Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis","volume":"277","author":"Sleat","year":"1997","journal-title":"Science"},{"key":"2021111618233851400_B8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1212\/01.wnl.0000267885.47092.40","article-title":"Neurological deterioration in late infantile neuronal ceroid lipofuscinosis","volume":"69","author":"Worgall","year":"2007","journal-title":"Neurology"},{"key":"2021111618233851400_B9","doi-asserted-by":"crossref","first-page":"9117","DOI":"10.1523\/JNEUROSCI.2729-04.2004","article-title":"A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration","volume":"24","author":"Sleat","year":"2004","journal-title":"J. Neurosci."},{"key":"2021111618233851400_B10","doi-asserted-by":"crossref","first-page":"20423","DOI":"10.1074\/jbc.R110.134452","article-title":"Common and uncommon pathogenic cascades in lysosomal storage diseases","volume":"285","author":"Vitner","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2021111618233851400_B11","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/hmg\/ddq555","article-title":"Disruption of adaptive energy metabolism and elevated ribosomal p-S6K1 levels contribute to INCL pathogenesis: partial rescue by resveratrol","volume":"20","author":"Wei","year":"2011","journal-title":"Hum. Mol Genet."},{"key":"2021111618233851400_B12","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbrc.2007.12.187","article-title":"Enhanced autophagy and mitochondrial aberrations in murine G(M1)gangliosidosis","volume":"367","author":"Takamura","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021111618233851400_B13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbrc.2011.11.016","article-title":"Involvement of the mitochondrial compartment in human NCL fibroblasts","volume":"416","author":"Pezzini","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021111618233851400_B14","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1002\/jcp.23021","article-title":"Crosstalk between mitochondrial (dys)function and mitochondrial abundance","volume":"227","author":"Michel","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"2021111618233851400_B15","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.biocel.2009.03.007","article-title":"The cell-type specificity of mitochondrial dynamics","volume":"41","author":"Kuznetsov","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021111618233851400_B16","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.cellsig.2011.05.021","article-title":"The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery","volume":"23","author":"Palmer","year":"2011","journal-title":"Cell. Signal."},{"key":"2021111618233851400_B17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ajmg.c.31317","article-title":"Autophagy and mitochondria in Pompe disease: nothing is so new as what has long been forgotten","volume":"160","author":"Raben","year":"2012","journal-title":"Am. J. Med. Genet. C, Semin. Med. Genet."},{"key":"2021111618233851400_B18","doi-asserted-by":"crossref","first-page":"39041","DOI":"10.1074\/jbc.M607982200","article-title":"Mitochondrial aberrations in mucolipidosis Type\u00a0IV","volume":"281","author":"Jennings","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2021111618233851400_B19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.4161\/auto.6.7.13099","article-title":"Abnormal mitochondrial autophagy in nephropathic cystinosis","volume":"6","author":"Sansanwal","year":"2010","journal-title":"Autophagy"},{"key":"2021111618233851400_B20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.molcel.2009.10.021","article-title":"GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca(2+)-dependent mitochondrial apoptosis","volume":"36","author":"Sano","year":"2009","journal-title":"Mol. Cell"},{"key":"2021111618233851400_B21","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s10545-010-9203-6","article-title":"Insights into novel cellular injury mechanisms by gene expression profiling in nephropathic cystinosis","volume":"33","author":"Sansanwal","year":"2010","journal-title":"J. Inherit. Metab. Dis."},{"key":"2021111618233851400_B22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1042\/bj20030598","article-title":"Enhanced expression of manganese-dependent superoxide dismutase in human and sheep CLN6 tissues","volume":"376","author":"Heine","year":"2003","journal-title":"Biochem. J."},{"key":"2021111618233851400_B23","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1042\/BJ20070319","article-title":"Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak","volume":"405","author":"Kubli","year":"2007","journal-title":"Biochem. J."},{"key":"2021111618233851400_B24","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1128\/MCB.20.15.5454-5468.2000","article-title":"BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore","volume":"20","author":"Vande Velde","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"2021111618233851400_B25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1042\/bj3570049","article-title":"Production and characterization of recombinant human CLN2 protein for enzyme-replacement therapy in late infantile neuronal ceroid lipofuscinosis","volume":"357","author":"Lin","year":"2001","journal-title":"Biochem. J."},{"key":"2021111618233851400_B26","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1128\/MCB.23.3.1085-1094.2003","article-title":"Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone","volume":"23","author":"Wilson-Fritch","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"2021111618233851400_B27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/978-1-59745-542-8_51","article-title":"Imaging systems for westerns: chemiluminescence vs. infrared detection","volume":"536","author":"Mathews","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"2021111618233851400_B28","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/toxsci\/kfg196","article-title":"Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes","volume":"75","author":"de Longueville","year":"2003","journal-title":"Toxicol. Sci."},{"key":"2021111618233851400_B29","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0091-679X(06)80030-0","article-title":"Visualization and quantification of mitochondrial dynamics in living animal cells","volume":"80","author":"De Vos","year":"2007","journal-title":"Methods Cell Biol."},{"key":"2021111618233851400_B30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1267\/ahc.07002","article-title":"Quantitative colocalization analysis of multicolor confocal immunofluorescence microscopy images: pushing pixels to explore biological phenomena","volume":"40","author":"Zinchuk","year":"2007","journal-title":"Acta Histochem. Cytochem."},{"key":"2021111618233851400_B31","doi-asserted-by":"crossref","first-page":"C350","DOI":"10.1152\/ajpcell.2001.281.1.C350","article-title":"Ionomycin causes activation of p38 and p42\/44 mitogen-activated protein kinases in human neutrophils","volume":"281","author":"Elzi","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2021111618233851400_B32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF00691335","article-title":"Mitochondrial alterations in the spinal ganglion neurons in ageing rats","volume":"54","author":"Vanneste","year":"1981","journal-title":"Acta Neuropathol."},{"key":"2021111618233851400_B33","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/cyto.a.20033","article-title":"Efficacy of MitoTracker Green and CMXrosamine to measure changes in mitochondrial membrane potentials in living cells and tissues","volume":"61","author":"Pendergrass","year":"2004","journal-title":"Cytometry A"},{"key":"2021111618233851400_B34","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1038\/onc.2009.49","article-title":"BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions","volume":"27","author":"Chinnadurai","year":"2008","journal-title":"Oncogene"},{"key":"2021111618233851400_B35","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/ijc.21547","article-title":"The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: implications for glioblastoma multiforme tumor cell survival under hypoxia","volume":"118","author":"Burton","year":"2006","journal-title":"Int. J. Cancer"},{"key":"2021111618233851400_B36","doi-asserted-by":"crossref","first-page":"H1924","DOI":"10.1152\/ajpheart.00368.2011","article-title":"Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes","volume":"301","author":"Lee","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021111618233851400_B37","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/cdd.2010.146","article-title":"Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover","volume":"18","author":"Rikka","year":"2011","journal-title":"Cell Death Differ."},{"key":"2021111618233851400_B38","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/embor.2010.50","article-title":"The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms","volume":"11","author":"Landes","year":"2010","journal-title":"EMBO Rep."},{"key":"2021111618233851400_B39","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1074\/jbc.M607279200","article-title":"Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission","volume":"282","author":"Taguchi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2021111618233851400_B40","doi-asserted-by":"crossref","first-page":"20710","DOI":"10.1074\/jbc.M110.213538","article-title":"Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein","volume":"286","author":"Nakamura","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2021111618233851400_B41","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1083\/jcb.201007013","article-title":"Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin","volume":"191","author":"Tanaka","year":"2010","journal-title":"J. Cell Biol."},{"key":"2021111618233851400_B42","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbrc.2007.04.106","article-title":"Simple quantitative detection of mitochondrial superoxide production in live cells","volume":"358","author":"Mukhopadhyay","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021111618233851400_B43","doi-asserted-by":"crossref","first-page":"R1134","DOI":"10.1152\/ajpregu.00842.2010","article-title":"Mitochondrial reactive oxygen species and calcium uptake regulate activation of phagocytic NADPH oxidase","volume":"302","author":"Dikalov","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Compar. Physiol."},{"key":"2021111618233851400_B44","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ymeth.2008.09.025","article-title":"Chemical calcium indicators","volume":"46","author":"Paredes","year":"2008","journal-title":"Methods"},{"key":"2021111618233851400_B45","doi-asserted-by":"crossref","first-page":"H2025","DOI":"10.1152\/ajpheart.00552.2008","article-title":"Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion","volume":"295","author":"Kubli","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021111618233851400_B46","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1089\/ars.2007.1726","article-title":"Regulation of Bnip3 death pathways by calcium, phosphorylation, and hypoxia-reoxygenation","volume":"9","author":"Graham","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"2021111618233851400_B47","doi-asserted-by":"crossref","first-page":"19318","DOI":"10.1073\/pnas.0804871105","article-title":"Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission\/fusion proteins","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111618233851400_B48","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.1171091","article-title":"S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury","volume":"324","author":"Cho","year":"2009","journal-title":"Science"},{"key":"2021111618233851400_B49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbadis.2011.10.016","article-title":"Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease","volume":"1822","author":"Reddy","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111618233851400_B50","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1471-4159.2011.07581.x","article-title":"Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease","volume":"120","author":"Sheng","year":"2012","journal-title":"J. Neurochem."},{"key":"2021111618233851400_B51","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/hmg\/ddr541","article-title":"Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease","volume":"21","author":"Johri","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"2021111618233851400_B52","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1093\/hmg\/ddr610","article-title":"Impaired parkin-mediated mitochondrial targeting to autophagosomes differentially contributes to tissue pathology in lysosomal storage diseases","volume":"21","author":"de Pablo-Latorre","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"2021111618233851400_B53","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ymgme.2009.07.002","article-title":"Inhibition of autophagosome formation restores mitochondrial function in mucolipidosis II and III skin fibroblasts","volume":"98","author":"Otomo","year":"2009","journal-title":"Mol. Genet. Metab."},{"key":"2021111618233851400_B54","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.neurobiolaging.2005.12.006","article-title":"You say lipofuscin, we say ceroid: defining autofluorescent storage material","volume":"27","author":"Seehafer","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"2021111618233851400_B55","doi-asserted-by":"crossref","first-page":"17783","DOI":"10.1074\/jbc.M901902200","article-title":"Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis","volume":"284","author":"Zunino","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2021111618233851400_B56","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1146\/annurev.pa.32.040192.002455","article-title":"Biochemical and molecular pharmacology of finin receptors","volume":"32","author":"Farmer","year":"1992","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2021111618233851400_B57","doi-asserted-by":"crossref","first-page":"815","DOI":"10.7164\/antibiotics.31.815","article-title":"Ionomycin, a new polyether antibiotic","volume":"31","author":"Liu","year":"1978","journal-title":"J. Antibiot."},{"key":"2021111618233851400_B58","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.biocel.2009.04.010","article-title":"Structural and functional link between the mitochondrial network and the endoplasmic reticulum","volume":"41","author":"Giorgi","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021111618233851400_B59","doi-asserted-by":"crossref","first-page":"re1","DOI":"10.1126\/stke.2152004re1","article-title":"Flirting in little space: the ER\/mitochondria Ca2+ liaison","volume":"2004","author":"Rizzuto","year":"2004","journal-title":"Sci. STKE"},{"key":"2021111618233851400_B60","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nature07534","article-title":"Mitofusin 2 tethers endoplasmic reticulum to mitochondria","volume":"456","author":"de Brito","year":"2008","journal-title":"Nature"},{"key":"2021111618233851400_B61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neulet.2009.06.011","article-title":"Hydrogen peroxide induces autophagic cell death in C6 glioma cells via BNIP3-mediated suppression of the mTOR pathway","volume":"461","author":"Byun","year":"2009","journal-title":"Neurosci. Lett."},{"key":"2021111618233851400_B62","doi-asserted-by":"crossref","first-page":"e17998","DOI":"10.1371\/journal.pone.0017998","article-title":"EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS ONE"},{"key":"2021111618233851400_B63","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2202-10-113","article-title":"Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation","volume":"10","author":"Zhao","year":"2009","journal-title":"BMC Neurosci."},{"key":"2021111618233851400_B64","first-page":"6669","article-title":"HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors","volume":"61","author":"Sowter","year":"2001","journal-title":"Cancer Res."},{"key":"2021111618233851400_B65","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmet.2007.11.001","article-title":"FoxO3 controls autophagy in skeletal muscle in\u00a0vivo","volume":"6","author":"Mammucari","year":"2007","journal-title":"Cell Metab."},{"key":"2021111618233851400_B66","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/CIRCRESAHA.107.164731","article-title":"The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes","volume":"102","author":"Yurkova","year":"2008","journal-title":"Circ. Res."},{"key":"2021111618233851400_B67","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1007\/s00125-010-1696-x","article-title":"Deficiency of Atf3, an adaptive-response gene, protects islets and ameliorates inflammation in a syngeneic mouse transplantation model","volume":"53","author":"Zmuda","year":"2010","journal-title":"Diabetologia"},{"key":"2021111618233851400_B68","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1038\/emboj.2011.248","article-title":"p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death","volume":"30","author":"Feng","year":"2011","journal-title":"EMBO J."},{"key":"2021111618233851400_B69","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1161\/01.RES.0000251744.06138.50","article-title":"Transcriptional silencing of the death gene BNIP3 by cooperative action of NF-\u03baB and histone deacetylase 1\u00a0in ventricular myocytes","volume":"99","author":"Shaw","year":"2006","journal-title":"Circ. Res."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20120104\/476145\/bsr033e023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20120104\/476145\/bsr033e023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T18:55:19Z","timestamp":1637088919000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/33\/2\/e00023\/56276\/Different-molecular-mechanisms-involved-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,7]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20120104","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,7]]},"article-number":"e00023"}}