{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:36:51Z","timestamp":1753871811898,"version":"3.41.2"},"reference-count":26,"publisher":"Portland Press Ltd.","issue":"4","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":1454,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:p>The transforming growth factor type\u00a0III receptor (T\u03b2RIII), also known as \u03b2-glycan, is a multi-functional sensor that regulates growth, migration and apoptosis in most cancer cells. We hereby investigated the expression of T\u03b2RIII in clinical specimens of tongue squamous cell carcinoma (TSCC) and the underlying mechanism that T\u03b2RIII inhibits the growth of CAL-27 human oral squamous cells. The TSCC tissues showed a significant decrease in T\u03b2RIII protein expression as detected by immunohistochemistry (IHC) and western blot analysis. Transfection of T\u03b2RIII-containing plasmid DNA dramatically promoted TGF-\u03b21 (10\u00a0ng\/ml)-induced decrease in cell viability, apoptosis and cell arrest at the G0-\/G1-phase. Moreover, transient overexpression of T\u03b2RIII enhanced the TGF-\u03b21-induced cyclin-dependent kinase inhibitor 2b (CDKN2b) and p38 protein activity, but did not affect the activities of extracellular signal-regulated kinase 1\/2 (ERK1\/2) and c-Jun N-terminal kinase 1\/2 (JNK1\/2) in CAL-27 cells. These results suggest overexpression of T\u03b2RIII receptor restored TGF-\u03b21 sensitivity in CAL-27 cells, which may provide some new insights on exploiting this molecule therapeutically.<\/jats:p>","DOI":"10.1042\/bsr20150141","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:05:58Z","timestamp":1438041958000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Overexpression of transforming growth factor type\u00a0III receptor restores TGF-\u03b21 sensitivity in human tongue squamous cell carcinoma cells"],"prefix":"10.1042","volume":"35","author":[{"given":"Duo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, P. R. 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2015,8,28]]},"reference":[{"key":"2021111618212449400_B1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics, 2013","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J. 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